便短链脂肪酸与妊娠期糖尿病中的肥胖有关
Katja Molan1, Jerneja Ambrožič Avguštin2, Matevž Likar2
1Faculty of Health Sciences, University of Novo mesto, 8000 Novo mesto, Slovenia.
Biomedicines
|February 26, 2025
概括
像乙酸和酸等短链脂肪酸 (SCFA) 在患有妊娠糖尿病的超重/肥胖孕妇中较高. 酸盐水平在怀孕期间过度体重增加时增加,这表明复杂的SCFA角色.
科学领域:
- 微生物组和宿主新陈代谢
- 生殖内分泌学 生殖内分泌学
- 营养生物化学 营养生物化学
背景情况:
- 短链脂肪酸 (SCFA) 是微生物发酵产物,对宿主新陈代谢至关重要.
- 脂肪酸调节母亲的新陈代谢,影响怀孕期间的体重,葡萄糖和荷尔蒙.
- 孕期糖尿病 (GDM) 在怀孕期间呈现出独特的代谢挑战.
研究的目的:
- 研究患有GDM的女性中SCFA配置文件和孕前孕产妇体重类别之间的关联.
- 探索SCFA度与过度妊娠体重增加之间的关系.
- 澄清SCFA在GDM和与怀孕相关的代谢变化中的复杂作用.
主要方法:
- 在2017年招募的45名患有GDM的女性进行长度研究.
- 在怀孕的第二和第三个三个月收集便样本.
- 高性能液态染色学 (HPLC) 分析用于酸盐,酸盐和丁酸盐的量化.
主要成果:
- 在超重/肥胖的GDM患者中,乙酸和酸的度明显高于正常体重患者.
- 体重类别之间没有观察到丁酸盐度的显著差异.
- 在孕期体重增加过多的妇女中,在孕期第三季度发现了酸盐水平的升高.
结论:
- SCFA-肥胖关系是复杂的,需要在GDM的背景下进行进一步的研究.
- 较高的酸盐和酸盐水平与妊娠前超重/肥胖有关.
- 增加的丁酸盐与过度的妊娠体重增加有关,强调其在妊娠体重管理中的潜在作用.
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