怀孕期间母体咖啡因消费对胎儿的影响 - - 综述
Rajani Dube1, Subhranshu Sekhar Kar2, Shadha Nasser Mohammed Bahutair1
1Department of Obstetrics and Gynecology, RAK College of Medical Sciences (RAKCOMS), RAK Medical & Health Sciences University (RAKMHSU), Ras Al-Khaimah P.O. Box 11172, United Arab Emirates.
Biomedicines
|February 26, 2025
概括
怀孕期间母亲的咖啡因消费与流产,死产和低出生体重等不良结果有关,即使每天低于200毫克. 基于证据的指导对于孕妇关于咖啡因摄入风险至关重要.
科学领域:
- 产科和妇科 产科和妇科
- 围产儿医学 围产儿医学
- 公共卫生 公共卫生
背景情况:
- 咖啡因被广泛消费,许多孕妇每天习惯性地摄入咖啡因.
- 母亲摄入的咖啡因很容易穿越生物障碍,包括胎盘,影响胎儿的发育.
- 现有研究表明,咖啡因消费与新生儿不良后果之间存在联系.
研究的目的:
- 调查母亲咖啡因摄入量与不良妊娠结果之间的关联.
- 评估当前卫生专业人员关于母亲咖啡因消费的建议.
- 综合关于咖啡因在妊娠期间的风险的证据.
主要方法:
- 从PubMed,Embase和Scopus的文献进行叙事审查.
- 包括病例控制研究,队列研究,随机对照试验和元分析.
- 分析的重点是检查母亲咖啡因使用和怀孕结果的研究.
主要成果:
- 母亲摄入咖啡因与流产,死产和低出生体重的风险增加有关.
- 摄入咖啡因的母亲生下的婴儿可能比妊娠年龄小.
- 观察到潜在的神经发育影响,儿童肥胖和急性白血病的联系,即使在低剂量.
结论:
- 怀孕期间的咖啡因消费对严重的妊娠结果构成重大风险.
- 遗传因素和表观遗传变化可能会影响个体对咖啡因的反应.
- 对于孕妇关于咖啡因摄入的明确,基于证据的指导是非常必要的.
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