暴露于聚烯微塑料的肠道微生物群中的代谢重编程
Jinhua Chi1,2, Jeffrey S Patterson1, Yan Jin2
1College of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA.
Biomedicines
|February 26, 2025
概括
微塑料 (MP) 暴露显著改变了肠道微生物群的组成和功能,在体外和体内. 这些变化会影响微生物的新陈代谢,可能会影响人类的健康.
科学领域:
- 环境科学 环境科学
- 微生物学 微生物学
- 毒理学 毒理学 毒理学
背景情况:
- 微塑料 (MP) 是无处不在的环境污染物,具有潜在的健康风险.
- 全球塑料生产导致了国会议员对环境的广泛污染.
- 由于其潜在的生态和人类健康影响,国会议员越来越关注公共卫生问题.
研究的目的:
- 研究微塑料 (MP) 暴露对肠道微生物群组成和功能的影响.
- 探索新陈代谢重编程在MP诱导的肠道失调症中的作用.
- 提供有关MP暴露对人类健康影响的机制性见解.
主要方法:
- 在体外培养的细菌菌株 (大肠杆菌,乳酸菌 rhamnosus) 暴露于聚烯MPs.
- 液体染色学-质谱学 (LC-MS) 用于非向的代谢分析.
- 在暴露于MPs的小鼠肠道微生物群上进行16S rRNA测序和向/非向代谢.
主要成果:
- 暴露于MP可以以剂量依赖的方式降低细菌生长.
- 代谢途径的显著变化,包括硫代谢,氨基糖代谢和能量生产途径 (糖解,酸途径).
- 暴露于MP导致肠道微生物组成的显著变化,包括乳酸菌的上调和化菌的减少.
结论:
- 暴露于微塑料会导致肠道微生物群的全面变化,影响其组成和功能.
- 代谢重编程,特别是在托代谢和能量通路中,是MP毒性的关键机制.
- 研究结果表明,暴露于微塑料对人类健康有相关性的潜在机械效应.
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