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经外科手术的多王国肠道微生物群改变冠状动脉旁路移植
Zhou Fu1,2, Yanxiong Jia1,2, Jing Zhao1,2
1Department of Cardiovascular Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
Biomedicines
|February 26, 2025
概括
冠状动脉旁路移植 (CABG) 手术显著改变肠道微生物群,减少有益细菌,增加有害微生物. 多王国肠道微生物群的这些变化会影响患者的健康和术后恢复.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 心血管外科心血管外科
背景情况:
- 冠状动脉旁路移植 (CABG) 是冠状动脉心脏病 (CHD) 的首要治疗方法.
- 肠道微生物群的改变与心脏病有关,但多个微生物王国的CABG后变化仍然不清楚.
研究的目的:
- 在CABG后的早期术后期间调查多王国肠道微生物群组成和功能的动态变化.
主要方法:
- 在CABG前和一周后,从40名患者收集了便样本.
- 使用元基因组测序来分析便样本中的微生物谱和功能基因.
主要成果:
- 在CABG后观察到多王国肠道微生物群和基因功能的显著转变.
- 有益的细菌 (例如Bifidobacterium, Bacteroides) 的数量减少,而有害的细菌 (例如Enterococcus) 的数量增加.
- 菌类和古生物种群发生了变化,其中Saccharomyces cerevisiae的具体增加和Methanomethylovorans-SGB40959.9的减少.
- 观察到Enterococcus病毒EFP01的显著增加,与Enterococcus丰富度相关.
- 确定了基因功能的术后失调,包括依赖烯酸酸的糖转化酶系统 (PTS).
结论:
- CABG手术诱导了细菌,真菌,古生物和病毒在肠道微生物群中的实质性改变.
- 观察到的有益微生物的减少和病原性微生物的增加凸显了对CABG后患者健康的潜在临床影响.
- 调节肠道微生物群可能提供未来的治疗策略,以改善CABG患者的治疗结果.
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