在炎症性和非炎症性扩展性心肌病症中,Midkine血清水平
Ulrich Grabmaier1,2, Bartolo Ferraro1,3, Kristin Lehnert4,5
1Medizinische Klinik und Poliklinik I, Ludwig-Maximilians-University Hospital, 81377 Munich, Germany.
Biomedicines
|February 26, 2025
概括
与健康个体相比,扩张性心肌病 (DCM) 和炎症性DCM (DCMi) 的患者中Midkine (MK) 水平较高. 然而,MK并没有区分DCM和DCMi,作为诊断生物标志物失败了.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 扩张性心肌病 (DCM) 和炎症性DCM (DCMi) 需要不同的治疗方法.
- 需要一个可靠的血清生物标志物来区分DCM和DCMi.
- 中基因 (MK) 是一种具有潜在生物标志物实用性的炎症性细胞因子.
研究的目的:
- 研究中 (MK) 作为一种血清生物标志物,用于区分DCM和DCMi.
- 评估MK水平与心力衰竭患者临床参数的相关性.
主要方法:
- 54名疑似心脏炎症的心力衰竭患者的回顾性分析.
- 内心肌组织活检来诊断DCM与DCMi.
- 测量了血清MK和NT-proBNP水平,并与13名健康对照进行了比较.
主要成果:
- 与DCM相比,DCMi活检显示免疫细胞 (巨细胞,T细胞) 和病毒基因组增加.
- 与健康对照组相比,DCM和DCMi患者的血清MK水平都较高.
- 在DCM和DCMi组之间没有发现MK水平的显著差异.
- MK水平与NYHA类,NT-proBNP或LVEDD没有相关性;在随访时观察到与LVEF的弱相关性.
结论:
- 在DCM和减少喷射分数的患者中,midkine (MK) 血清水平升高.
- 米德凯恩 (MK) 不能区分DCM和DCMi.
- 中基因 (MK) 不是区分DCM和DCMi的合适生物标志物.
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