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Updated: May 25, 2025

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环境暴露,铁代谢,血标志物和类风湿关节炎之间的因果关系:使用孟德尔随机化的调查

Chao Wang1,2, Wenqing Xie1,2, Chenggong Wang1,2

  • 1Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, China.

Biomedicines
|February 26, 2025
PubMed
概括

吸烟显著增加了类风湿性关节炎 (RA) 的风险,特别是血清阳性RA,C-反应蛋白作为关键调解剂. 减少吸烟暴露对于打击RA的公共卫生战略至关重要.

关键词:
门德尔的随机化全基因组关联研究研究.血标志物 血标志物 血标志物铁的平衡是铁的平衡.类风湿性关节炎 类风湿性关节炎

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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