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暴露于 perfluorooctane sulfonate (PFOS) 的鱼 (Carassius auratus) 的肝毒性:综合性组织病理学和转录学分析

Lin Tang¹, Guijie Hao², Dongren Zhou²

¹Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou 310014, China.

Animals : an open access journal from MDPI

|February 26, 2025

概括

perfluorooctane sulfonate (PFOS) 污染了水生环境,导致鱼的肝脏受损. 这项研究揭示了PFOS破坏脂质代谢,能量生产和免疫反应,突出了其生态毒理学风险.

科学领域:

环境毒理学环境毒理学
水生生态毒理学水生生态毒理学
分子生物学分子生物学

背景情况:

perfluorooctane sulfonate (PFOS) 是一种具有广泛分布的持久性环境污染物.
对于PFOS对水生生物的毒性影响,特别是对鱼类肝脏健康的影响,尚未完全理解.
鱼是水生生态系统健康的关键指标物种.

研究的目的:

为了研究PFOS在鱼中的肝毒性.
为了阐明PFOS诱导的肝损伤背后的分子机制.
评估PFOS对水生生物的生态毒理风险.

主要方法:

在鱼中确定PFOS的96小时LC50.
肝脏组织的组织病理学检查.
转录组分析以确定差异表达基因 (DEG) 和受影响的通路.

主要成果:

96小时的LC50被确定为23.17 mg/L.
组织病理学揭示了PFOS诱导的肝损伤,包括静脉拥堵,核细胞溶解和细胞真空化.
转录组分析确定了1036个参与脂质/能量代谢,免疫和内分泌调节的DEG,这表明与非酒精性脂肪肝疾病 (NAFLD) 相关的途径.

结论:

对于鱼来说,PFOS具有急性毒性,导致严重的肝损伤.
暴露于PFOS会破坏关键的生理途径,包括脂质和能量代谢,免疫功能和内分泌信号.
这项研究提供了关于PFOS生态毒性的见解,并为减轻水污染和保护生态系统健康的战略提供了信息.

关键词:

这就是为什么PFOS是PFOS.克鲁西安鱼是一种鱼.组织病理学组织病理学脂质新陈代谢脂质新陈代谢欧米克斯分析分析

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