中度晚期早产婴儿的扭曲运动和低血糖症:一项前性队列研究
Javier Merino-Andrés1,2, Francisco Javier Fernández-Rego3,4, Álvaro Hidalgo-Robles5
1Toledo Physical Therapy Research Group (GIFTO), Faculty of Physical Therapy and Nursing, University of Castilla-La Mancha, 45071 Toledo, Spain.
Children (Basel, Switzerland)
|February 26, 2025
概括
早产婴儿的低血糖与异常的一般运动有关. 早期监测血糖和运动模式对于这些脆弱的婴儿的神经发育结果至关重要.
科学领域:
- 新生儿医学 新生儿医学
- 发育儿科 发育儿科
- 神经科学是一个神经科学.
背景情况:
- 中期到晚期的早产婴儿是全球最大的早产群体.
- 这种人群面临神经发育障碍的风险增加.
- 低血糖是早产婴儿常见和显著的危险因素.
研究的目的:
- 为了研究低血糖和早产后早产婴儿的一般运动模式之间的关联.
- 在这个特定的婴儿群体中评估一般运动评估的可靠性.
- 为了确定早产婴儿患有低血糖症的潜在神经发育指标.
主要方法:
- 在NICU中对中晚期早产婴儿进行前性单中心队列研究.
- 使用Prechtl的一般运动评估评估的一般运动.
- 使用FreeStyle OptiumTM Neo血糖计监测血糖水平;通过Fisher的精确测试进行统计分析,通过ICC和kappa系数进行可靠性.
主要成果:
- 17名患有低血糖 (<45 mg/dL) 的早产婴儿显示出高患病率 (58.8%) 的一般运动表达不佳.
- 在35.2%的低血糖婴儿中观察到正常的一般运动模式.
- 在运动评估中发现了良好的观察者间可靠性 (ICC = 0.7) 和中度可靠性 (kappa = 0.4).
结论:
- 中度至晚期早产婴儿的过渡性低血糖症经常与不良的总体运动模式相关.
- 常规监测一般运动是评估神经发育状况的可靠工具在早期的产后早产婴儿.
- 这些发现强调了对早产婴儿低血糖和相关运动异常的警监测的重要性.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Pathophysiology of Diabetes
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Hypoglycemia and Glucagon
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
Type I Diabetes III: Clinical Manifestations
Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
Hypoglycemia
Hypoglycemia is a blood glucose level below 70 mg/dL. It commonly occurs in individuals using insulin or insulin-secreting drugs, but may also arise in non-diabetic conditions. People with type 1 diabetes are at the highest risk because they depend on exogenous insulin. People with type 2 diabetes are also at risk, especially when treated with insulin or medications such as sulfonylureas, which increase insulin release regardless of blood glucose levels. It develops when insulin levels exceed...
Hyperglycemia
Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...


