脊柱二叉脊柱的儿科患者的结肠计量:从回顾性队列研究的结果
Albert Yuh Chyuan Shan1, Barry Duel2, Timothy Phillips2
1Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cardinal Glennon Children's Medical Center, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.
Children (Basel, Switzerland)
|February 26, 2025
概括
在脊柱裂变 (SB) 患者中,神经性肠功能障碍可能源于直肠问题或缓慢过渡便秘 (STC),而不是结肠运动问题. 优先考虑保守治疗,而不是SB肠道管理的侵入性选择.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 神经胃肠病学 神经胃肠病学
- 脊髓损伤研究 脊髓损伤研究
背景情况:
- 神经性肠道功能障碍是脊柱裂变 (SB) 患者的常见并发症.
- 在SB患者中,耐火性肠道症状背后的精确机制,特别是结肠运动性,尚未完全理解.
研究的目的:
- 为了研究脊柱裂患者的结肠机动性,这些患者经历了耐火性神经性肠功能障碍.
- 为了区分阳功能障碍,慢过渡性便秘 (STC) 和结肠机动性对SB的肠道问题的贡献,SB.
主要方法:
- 对13名患有难治性肠功能障碍的骨髓瘤细胞瘤患者进行了回顾性队列研究.
- 患者接受了肠道治疗方案优化,直肠计量 (ARM),结肠过渡时间 (CTT) 研究或结肠计量 (CM).
主要成果:
- 在12名接受治疗的患者中,有4人实现了肠道不排便.
- 在5名进行高级运动测试的患者中:有2人有异常的ARM,有3人中有1人有异常的CTT,所有5人均有正常的结肠力度测试 (CM).
结论:
- 阳门功能障碍和STC更有可能导致SB中的耐火性肠道症状,而不是大肠运动障碍.
- 在考虑SB中神经性肠道功能障碍的侵入性检查或手术干预之前,应优化保守疗法,包括刺激性药.
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