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通用和品牌Cefepime有效性的比较分析:一个多中心的回顾性队列研究

Chih-Huang Li^1,2, Peng-Hao Chang^2,3, Ching-Tai Huang^2,3

¹Department of Emergency Medicine, Chang Gung Memorial Hospital Linkou Medical Center, Taoyuan 33342, Taiwan.

Life (Basel, Switzerland)

|February 26, 2025

概括

在现实世界中使用时,通用塞菲皮姆与品牌塞菲皮姆一样有效和安全. 这一发现支持仿制药Cefepime作为一种具有成本效益的替代品,而不会影响患者的治疗结果.

科学领域:

药理学药理学是指药理学的学科.
传染性疾病传染性疾病
卫生经济学卫生经济学

背景情况:

在现实环境中,仿制药与品牌Cefepime的临床有效性尚未得到充分证实.
了解比较的疗效和安全性对于医疗保健成本和患者的治疗结果至关重要.
塞菲皮姆是一种广泛使用的第四代类抗生素.

研究的目的:

为了比较仿制药和品牌Cefepime配方的临床疗效和安全性.
评估基于cefepime配方的真实世界患者结果.
确定仿制药cefepime是否提供了具有成本效益的替代品,而不会影响治疗结果.

主要方法:

多中心,回顾性队列研究 (2017-2022),包括接受塞费皮姆单疗的成年患者.
倾向性得分匹配用于控制人口统计,并发症和疾病严重程度的混变量.
分析主要结局 (住院死亡率) 和次要结局 (30天死亡率,再入院,住院时间,ICU住院,发作).

主要成果:

包括2370名患者;877人接受通用药,1493人接受品牌Cefepime.
在匹配后,在通用和品牌Cefepime组之间没有观察到在医院死亡率 (p=0.841) 或二次结果的显著差异.
在两种配方中都发现了可比的生物标志物趋势和临床恢复模式.

结论:

通用Cefepime在现实临床实践中证明了与品牌Cefepime相比的有效性和安全性.
通用cefepime代表了一种可行的,具有成本效益的治疗选择,不影响患者的治疗结果.
这项研究提供了证据支持使用仿制品cefepime作为品牌配方的替代品.

关键词:

这是一个很快的时间.有效性有效性.仿制药是一般药物的.在安全方面,安全是安全的.发作发作发作这是一种血症.

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