在COVID-19相关住院后的呼吸道肌肉功能障碍和相关风险因素
Alessia Verduri1, Roberto Tonelli1, Pierluigi Donatelli1
1Respiratory Unit, Hospital Policlinico Modena, Department of Surgical and Medical Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Life (Basel, Switzerland)
|February 26, 2025
概括
呼吸道肌肉功能障碍在严重的COVID-19幸存者中很常见,与非侵入性通风使用和女性性别有关. 建议对COVID-19后的患者进行最大吸气压 (MIP) 和最大呼气压 (MEP) 的评估.
科学领域:
- 肺部病理学 肺部病理学
- 关键护理医学 关键护理医学
- 康复医学 康复医学 康复医学
背景情况:
- 长期呼吸道肌肉功能障碍是COVID-19幸存者的已知并发症.
- 导致这种功能障碍的危险因素在很大程度上仍未确定.
- 这项研究调查了急性呼吸衰竭的住院COVID-19患者的呼吸肌功能和相关因素.
研究的目的:
- 在COVID-19幸存者中评估呼吸道肌肉功能 (MIP/MEP).
- 确定与呼吸道肌肉功能障碍相关的独立风险因素.
- 探索呼吸肌肉强度,手握强度和肺功能之间的相关性.
主要方法:
- 一个单一中心研究涉及223名COVID-19幸存者 (≥18岁) 离院3-6个月后.
- 收集的数据包括呼吸肌肉强度 (MIP/MEP),手握强度和肺功能参数 (FEV1,FVC,TLC,DLCO).
- 统计分析采用后勤回归模型来确定风险因素和相关性分析.
主要成果:
- 超过一半 (54.3%) 的患者表现出MIP或MEP功能障碍.
- 功能障碍的独立风险因素包括非侵入性通风使用 (aOR=1.91) 和女性性别 (aOR=1.76).
- MIP功能障碍与手握强度正相关;MIP和MEP都与肺功能指标有显著的相关性.
结论:
- 呼吸道肌肉功能障碍在严重的COVID-19幸存者中普遍存在,与外周软弱和肺功能减弱相关.
- 急性疾病期间的非侵入性通风和女性性别是潜在的风险因素.
- 建议对MIP/MEP进行常规评估,以监测COVID-19后患者的呼吸道肌肉功能.
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