患有慢性心力衰竭患者的左心室菌株与保存的喷射部分:叙述性审查
Dana Emilia Man1,2, Alexandru Catalin Motofelea3, Valentina Buda4
1University Clinic of Internal Medicine and Ambulatory Care, Prevention and Cardiovascular Recovery, Department VI-Cardiology, "Victor Babes" University of Medicine and Pharmacy, 3000041 Timisoara, Romania.
Life (Basel, Switzerland)
|February 26, 2025
概括
全球纵向应变 (GLS) 和左心房应变 (LAS) 是诊断心力衰竭与保留射出分数 (HFpEF) 的关键心声心脏学生物标志物. 它们的联合使用提供了改进的特征和个性化HFpEF治疗的潜力.
科学领域:
- 心脏病学 心脏病学
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
- 生物标志物 生物标志物
背景情况:
- 由于传统心声学参数的各种表现和局限性,诊断心力衰竭与保存的射出分数 (HFpEF) 是具有挑战性的.
- 左心房 (LA) 应变提供了对LA功能和左心室 (LV) 扩张功能的详细见解,这对于HFpEF评估至关重要.
- 目前的HFpEF诊断依赖于参数的组合,使标准化管理和精确的表征复杂化.
研究的目的:
- 评估全球纵向应变 (GLS) 和左心房应变 (LAS) 作为用于诊断和表征HFpEF的回声心脏学生物标志物.
- 审查压力成像在提供精细的心肌变形评估超出传统措施的作用.
- 探索将GLS和LAS结合在一起的潜力,以定义HFpEF现象组,并指导个性化治疗.
主要方法:
- 对评估HFpEF患者GLS和LAS的临床研究的综述.
- 应变成像的分析,特别是斑点跟踪回声心脏图像,用于心肌变形的评估.
- 讨论GLS和LAS的正常范围,考虑到人口和技术影响.
主要成果:
- GLS和LAS是HFpEF中确定的预后指标,有助于预测心血管结果,并将HFpEF与呼吸不良的其他原因区分开来.
- 应变测量为左心功能提供了详细的见解,这对于HFpEF的表征至关重要.
- 结合GLS和LAS在定义HFpEF现象组的过程中显示出潜在的定制疗法的前景.
结论:
- GLS和LAS是非侵入性HFpEF诊断和分层的核心.
- 虽然有价值,但应变测量中的可变性和假阴性风险需要谨慎的临床解释.
- 未来的指导方针应该推GLS和LAS的联合使用,以进行全面的HFpEF评估和管理.
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