以表观遗传学为基础的年龄加速与美国老年人的2,3,7,8 TCDD 暴露有关
Baek-Yong Choi1, Seung-Woo Ryoo1, Seok-Yoon Son1
1Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
International journal of molecular sciences
|February 26, 2025
概括
对2,3,7,8-四二二氧化 (TCDD) 的暴露与老年人加速表观遗传衰老有关. 这种有毒化学物质以剂量依赖的方式影响DNA甲基化钟,特别是与死亡率相关的DNA甲基化钟.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 2,3,7,8-四二二氧化 (TCDD) 是一种高度有毒的环境污染物,已知对健康有不良影响.
- 以前的研究表明,TCDD暴露可能会影响诸如端粒长度和精子DNA甲基化年龄等衰老标志物.
- 人类中TCDD和更广泛的表观遗传衰老之间的特定关系仍未得到充分研究.
研究的目的:
- 调查血清TCDD水平与老年人多重DNA甲基化基因表观遗传钟之间的关联.
- 为了确定TCDD暴露是否与表观遗传钟测量的加速生物衰老相关.
- 探索TCDD与表观遗传衰老之间的潜在剂量依赖和非线性关系.
主要方法:
- 分析了来自1999-2002年国家健康和营养检查调查的589名老年人 (50-79岁) 的数据.
- 使用高分辨率气色谱/同位素稀释高分辨率质谱测量血清TCDD水平.
- 评估六个基于DNA甲基化的表观遗传时钟 (Horvath年龄,Hannum年龄,SkinBlood年龄,Pheno年龄,Grim年龄,Grim年龄2) 使用全血DNA甲基化数据.
主要成果:
- 在TCDD水平和几个表观遗传时钟 (Horvath时代,Hannum时代,Pheno时代,阴暗时代,阴暗时代2) 之间发现了显著的关联.
- 在脂质调整后,对于PhenoAge和Grim Age2.2仍然存在显著的关联.
- 非线性趋势,表明值效应,最明显的是在PhenOAge,GrimAge和GrimAge2.
结论:
- 暴露于TCDD与老年人加速表观遗传衰老有关.
- TCDD对表观遗传衰老的影响,特别是对与死亡率相关的时钟的影响,似乎是剂量依赖的,非线性.
- 这些发现突出了TCDD作为环境因素的潜力,通过表观遗传机制影响衰老过程.
关键词:
通过DNA甲基化.二氧化二氧化的使用情况环境化学品环境化学品遗传表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表一般人口一般人口.相关概念视频
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