复习自闭症中偏高甲醇的升高以及对症状的可能影响
Christina K Flynn1,2, James B Adams1,2, Rosa Krajmalnik-Brown1,3
1Biodesign Center for Health Through Microbiomes, Arizona State University, Tempe, AZ 85287, USA.
International journal of molecular sciences
|February 26, 2025
概括
帕拉克雷索尔及其代谢物p-cresol硫酸盐与自闭症谱系障碍 (ASD) 有关. 患有自闭症儿童的高水平表明,这些来自肠道的化合物有助于核心症状和相关健康问题.
科学领域:
- 微生物组研究的研究.
- 神经科学是一个神经科学.
- 代谢学 代谢学 代谢学
背景情况:
- 帕拉克雷索尔 (p-cresol) 和p-cresol硫酸盐 (pCS) 是肠道衍生代谢物,与自闭症谱系障碍 (ASD) 有关.
- 与对照组相比,在患有自闭症的儿童中报告了尿液中p-cresol和pCS的升高水平.
- P-cresol对肠道,大脑,脏,免疫系统和线粒体产生有害影响,可能导致ASD和并发性疾病.
研究的目的:
- 审查将p-cresol和pCS与ASD联系在一起的证据.
- 探索这些代谢物可能影响ASD病理生理学的机制.
- 评估针对p-cresol生产或在ASD中的作用的治疗潜力.
主要方法:
- 对调查p-cresol,pCS和ASD的研究进行文献综述.
- 分析动物模型和人类临床试验的研究结果.
- 检查p-cresol对与ASD相关的生物系统的影响.
主要成果:
- 十七项研究发现,ASD儿童的p-cresol和/或pCS水平较高.
- P-cresol 破坏肠道微生物群,线粒体功能,神经元发育和免疫反应.
- 动物研究表明,p-cresol诱导与自闭症相关的行为,可通过便微生物群移植逆转.
- 在患有ASD的儿童中,微生物种移植治疗减少了pCS,改善了GI和ASD症状.
结论:
- P-cresol和pCS与ASD有很强的关联,并且可能会导致受影响儿童的重要部分的核心症状.
- 准肠道微生物群和降低p-cresol水平可能为ASD提供治疗策略.
- 需要进一步的研究来阐明确切的因果作用,并开发有效的干预措施.
相关概念视频
01:19Autism Spectrum Disorder
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Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
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01:30Attention-Deficit/Hyperactivity Disorder
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Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
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