相关实验视频

Updated: May 25, 2025

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

使用半孔纳米粒子开发一种加载于卡维迪醇的固体自我纳米乳化系统,具有提高的溶解度和生物可用性

Hangeul Jang¹, Nahyun Kim¹, Sung Giu Jin¹

¹Department of Pharmaceutical Engineering, Dankook University, 119 Dandae-ro, Dongnam-gu, Cheonan 31116, Republic of Korea.

International journal of molecular sciences

|February 26, 2025

概括

一种新型的固体自纳米乳化药物递送系统 (S-SNEDDS) 使用半孔纳米粒子 (MSN) 显著增强了卡维迪醇.

科学领域:

纳米技术纳米技术
材料科学材料科学材料科学
制药科学制药科学

背景情况:

难以溶解的药物对口服药物输送构成挑战.
卡维迪洛的低溶解度限制了其治疗效果.
开发先进的药物输送系统对于改善生物可用性至关重要.

研究的目的:

开发一种固体的自纳米乳化药物递送系统 (S-SNEDDS),以提高卡维迪洛的口服生物可用性.
为了利用半孔纳米粒子 (MSNs) 作为S-SNEDDS的载体.
优化S-SNEDDS配方,以提高药物的可溶性和溶解.

主要方法:

液体自纳米乳化药物输送系统 (L-SNEDDS) 的配方,使用卡维迪醇,佩西奥尔,Tween 80和Labrasol.
在MSN中暂停L-SNEDDS,然后喷雾干燥以创建S-SNEDDS.
评估各种MSN比率的乳液特性,可溶性和溶解概况.
使用DSC,XRD,FT-IR,粒子大小分析和SEM进行物理化学表征.

主要成果:

最佳的S-SNEDDS (MSN与L-SNEDDS的比例为500:1000) 形成了一个纳米乳液,并实现了显著的超和.
药物溶解度增加了大约400倍,溶解改善了大约5.7倍.
口服生物可用性标志物AUC和Cmax分别增加了21.7倍和15.7倍.
鉴定证实了MSN中的药物封装,由晶体转变为无形状态,并减少颗粒大小.

结论:

半孔纳米粒子 (MSN) 作为S-SNEDDS的有效和生物相容的载体.
开发的S-SNEDDS配方为改善可溶性较差的药物如卡维迪洛的口服输送提供了一个有前途的策略.
这种方法有助于更安全,更有效的药物输送系统.

关键词:

卡尔维迪醇是一种半孔的二氧化纳米粒子.固体自纳米乳化药物输送系统

更多相关视频

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

Preparation of Silica Nanoparticles Through Microwave-assisted Acid-catalysis

Preparation of Silica Nanoparticles Through Microwave-assisted Acid-catalysis

Published on: December 16, 2013

相关概念视频

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...

Factors Influencing Drug Absorption: Drug Dissolution

Factors Influencing Drug Absorption: Drug Dissolution

The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...