在SARS-CoV-2病毒上通过Pistacia vera L.及其胡卜素Zeaxanthin进行选择性控制
Rosamaria Pennisi1, Davide Gentile2, Paola Trischitta1,3
1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.
International journal of molecular sciences
|February 26, 2025
概括
pistachio 提取物在阻止 SARS-CoV-2 进入方面表现有前途,包括 Omicron 变种. 化合物泽亚桑丁通过与尖端蛋白和宿主细胞机制相互作用,有效地抑制病毒结合.
科学领域:
- 病毒学 病毒学
- 自然产品化学 自然产品化学
- 分子生物学分子生物学
背景情况:
- 由SARS-CoV-2引起的COVID-19大流行,由于病毒变异,耐药性和药物副作用,提出了挑战.
- 植物衍生化合物正在探索抗病毒特性,作为传统治疗的替代方案.
研究的目的:
- 调查 pistachio 提取物对 SARS-CoV-2 的抗病毒活性.
- 确定 pistachio 化合物,特别是 zeaxanthin 针对 SARS-CoV-2 变种的特定抑制机制.
主要方法:
- 使用伪型病毒颗粒显示SARS-CoV-2尖端蛋白.
- 用 pistachio 提取物和分离的 zeaxanthin 处理病毒颗粒.
- 在基分析中分析了泽亚桑丁与尖端蛋白的受体结合域 (RBD) 的相互作用.
- 评估山丁对宿主蛋白酶TMPRSS2表达的作用.
主要成果:
- 豆提取物显著抑制了SARS-CoV-2变种的α和ο微型的进入.
- 泽亚丁显示出变种特异性的抑制活性.
- 在 silico 研究显示强烈的芝丁-RBD 对Omicron的相互作用,阻止进入.
- 山丁与阿尔法变异的RBD的较弱相互作用不足以直接抑制.
- 山丁抑制了TMPRSS2的表达,阻碍了阿尔法变体的内部化.
结论:
- pistachio 提取物,特别是 zeaxanthin,具有抑制 SARS-CoV-2 进入的显著潜力.
- 泽亚桑丁的双重机制涉及尖端蛋白相互作用和宿主蛋白酶调节,为对抗SARS-CoV-2变种提供了一个有前途的治疗途径.
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