患有心脏参与或不涉及心脏参与的晶氨化症患者的不同肠道微生物组概况
João Henrique Rissato1, Natalia de Melo Pereira1, Cristhian Espinoza Romero1
1Heart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05508-220, Brazil.
International journal of molecular sciences
|February 26, 2025
概括
晶氨基粉症 (ATTR氨基粉症) 改变了肠道微生物群,影响了胃肠道症状和心脏健康. Streptococcus 和 Lachnospiraceae 等特定细菌与疾病严重程度和生物标志物有明显的相关性.
科学领域:
- 胃肠病学 胃肠病学
- 心脏病学 心脏病学
- 微生物学 微生物学
背景情况:
- 晶氨基粉症 (ATTR氨基粉症) 涉及粉素在器官中的积累,导致肠道失调.
- 在ATTR氨基粉症中,低 perfusion,和dysautonomia会破坏肠道微生物组的平衡.
研究的目的:
- 与对照人群相比,研究ATTR氨基粉症患者的肠道微生物组组成,有或没有心脏参与.
- 为了确定特定的肠道细菌和ATTR氨基粉症的临床参数之间的相关性.
主要方法:
- 使用16S rRNA基因测序,对60名参与者进行了肠道微生物组的分析 (包括心脏病的ATTR氨基粉症,没有心脏病的ATTR氨基粉症和对照组).
- 分析了临床数据,心声图,六分钟步行测试,心脏生物标志物 (热素,BNP) 和基因型.
主要成果:
- 与对照组相比,ATTR氨基粉症患者表现出不同水平的链球菌,Lachnospiraceae和Sellimonas.
- 对照组显示,甲诺斯菲拉的丰富性更高.
- estreptococcus 与较高的热波宁相关; 拉克诺斯皮拉家族具有较低的BNP和较小的左心房.
- 塞利莫纳斯与较高的肠道症状得分有关,而甲诺斯菲拉与较低的得分有关.
结论:
- 与健康个体相比,ATTR氨基粉症患者具有独特的肠道微生物组概况.
- 在ATTR氨基粉症中肠道微生物组的改变与基因型,胃肠道症状,心脏生物标志物和功能能力相关.
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