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在儿童1型糖尿病和过渡性高血糖症中对氧化应激反应的比较研究

Anca Daniela Pinzaru^1,2, Ancuta Lupu³, Tatiana Chisnoiu^1,2

¹Pediatrics, County Clinical Emergency Hospital of Constanta, 900591 Constanta, Romania.

International journal of molecular sciences

|February 26, 2025

概括

患有1型糖尿病 (T1DM) 的儿童表现出氧化应激标志物增加,如马隆迪甲 (MDA). 健康儿童的过渡性高血糖症并没有改变他们的氧化状态,与T1DM不同.

科学领域:

儿科内分泌学儿科内分泌学
氧化压力研究研究氧化压力研究
生物标记分析生物标记分析

背景情况:

过高血糖是1型糖尿病 (T1DM) 中氧化应激的已知触发因素.
了解氧化应激差异对于儿科T1DM管理至关重要,并将其与暂时高血糖症区分开来.

研究的目的:

为了比较患有T1DM的儿科患者和患有过渡性高血糖症的健康儿童之间的氧化应激生物标志物.
研究T1DM中氧化应激标志物和临床参数之间的关系.

主要方法:

一项涉及42名患有T1DM的儿科患者和1至6岁的健康对照者的病例控制研究.
对氧化应激生物标志物的血液样本分析,包括马隆迪甲 (MDA) 和谷氨过氧化酶 (GPx).
评估生物标志物,A1c,年龄,BMI,胰岛素剂量和脂质资料之间的相关性.

主要成果:

与对照组相比,T1DM患者的血MDA水平显著升高.
在谷氨 (GSH) 和糖尿病组之间观察到显著的负相关性.
虽然T1DM改变了,,脂质和氧化应激之间的关系,但健康儿童的过渡性高血糖症并没有显著改变其氧化状态.

结论:

儿科T1DM与氧化应激增加有关,其证据是MDA水平升高.
健康儿童的过渡性高血糖症似乎不会引起显著的氧化应激.
T1DM显著影响了必需矿物质,脂质和氧化应激标志物之间的相互作用.

关键词:

孩子们的孩子们的孩子们的孩子们.糖尿病糖尿病患者糖尿病患者氧化应激是一种氧化应激.过渡性高血糖症过渡性高血糖症

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