Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Inflammation01:38

Inflammation

52.2K
Overview
52.2K
Inflammatory Response01:28

Inflammatory Response

1.7K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
1.7K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

2.5K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
2.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

First-Line Dapagliflozin, Metformin, or Combination Therapy in Type 2 Diabetes: Vascular and Molecular Outcomes of a Randomised Controlled Trial.

Diabetes, obesity & metabolism·2026
Same author

Endothelial-immune cells-on-chip for multiplex evaluation of drug responses through patient plasma screening.

Stem cell research & therapy·2026
Same author

Genomic landscape of drug binding and pharmacogenetic variation across diverse populations using SNPdrug3D.

Nature communications·2026
Same author

Isolation of small extracellular vesicles from small volumes of blood plasma using size exclusion chromatography and density gradient ultracentrifugation.

eLife·2026
Same author

Angptl4 integrates dietary and microbial signals to disrupt gut barrier function in MASH.

Nature communications·2026
Same author

The oral-gut microbiome axis in diabetes mellitus: a systematic review and emerging clinical perspectives.

Diabetes research and clinical practice·2026

相关实验视频

Updated: May 25, 2025

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

6.5K

免疫,炎症和内皮功能障碍之间的相互作用

Ying Jie Chee1,2, Rinkoo Dalan1,2, Christine Cheung2,3

  • 1Department of Endocrinology, Tan Tock Seng Hospital, Singapore 308433, Singapore.

International journal of molecular sciences
|February 26, 2025
PubMed
概括

内皮在免疫和炎症中起着关键作用. 本综述探讨了内皮细胞如何调节免疫反应,并在代谢疾病中变得功能障碍,突出了新的治疗点.

关键词:
心血管疾病的心血管疾病它们的内皮质 (endothelium).免疫力是一种免疫力.这是一种炎症炎症炎症炎症.治疗剂 治疗剂 治疗剂

更多相关视频

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
12:55

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Published on: December 9, 2021

3.2K
On-Chip Endothelial Inflammatory Phenotyping
12:43

On-Chip Endothelial Inflammatory Phenotyping

Published on: July 21, 2012

10.8K

相关实验视频

Last Updated: May 25, 2025

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

6.5K
A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
12:55

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Published on: December 9, 2021

3.2K
On-Chip Endothelial Inflammatory Phenotyping
12:43

On-Chip Endothelial Inflammatory Phenotyping

Published on: July 21, 2012

10.8K

科学领域:

  • 心血管生物学 心血管生物学
  • 免疫学 免疫学 免疫学
  • 代谢疾病 代谢疾病

背景情况:

  • 内皮对于血管平衡,新陈代谢和免疫反应至关重要.
  • 最近的研究强调了内皮作为天生的免疫和适应性免疫之间的桥梁的作用.
  • 内皮功能障碍与诸如高血糖,肥胖,高血压和脂质失调等代谢障碍有关.

研究的目的:

  • 审查内皮细胞对免疫-炎症轴的调节.
  • 讨论内皮细胞的生理免疫功能.
  • 探索代谢干扰如何导致内皮功能障碍,并确定治疗点.

主要方法:

  • 关于内皮质,免疫和代谢疾病的最新研究的文献综述.
  • 对将内皮功能与免疫调节联系起来的分子机制的分析.
  • 确定针对内皮功能障碍中的免疫-炎症轴的治疗策略.

主要成果:

  • 内皮细胞积极调节先天性和适应性免疫和炎症.
  • 代谢障碍通过免疫-炎症通路显著损害内皮功能.
  • 新的治疗点正在出现,以解决代谢性疾病中的内皮功能障碍.

结论:

  • 内皮是免疫-炎症轴的中央调节器.
  • 代谢性疾病中的内皮功能障碍是由免疫-炎症过程驱动的.
  • 针对这些途径为心血管和代谢疾病提供了有前途的治疗途径.