在地球和太空飞行中关于神经衰老的更新
Nik V Kuznetsov1, Yauhen Statsenko1,2, Milos Ljubisavljevic1,3
1ASPIRE Precision Medicine Research Institute Abu Dhabi, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.
International journal of molecular sciences
|February 26, 2025
概括
本综述强调了脑衰老和神经退行过程中的表观遗传机制,特别是microRNAs. 了解这些分子过程是开发老化大脑诊断和干预措施的关键.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
背景情况:
- 大脑衰老涉及复杂的,非线性时间过程.
- 表观遗传机制,包括非编码RNA,在神经衰老中起着至关重要的作用.
- 遗传学,氧化应激,炎症,生活方式和环境暴露等因素有助于神经衰老.
研究的目的:
- 审查400多篇关于大脑衰老,神经衰老和神经退行症的病理生理学的文章.
- 专注于表观遗传机制和非编码RNA,特别是微RNA在衰老过程中的基因调节中的作用.
- 确定用于神经衰老诊断和对策的候选分子生物标志物.
主要方法:
- 对400多篇文章进行了全面的文献综述.
- 专注于表观遗传机制和非编码RNA,重点是微RNA.
- 分析影响衰老速度的因素,包括培训和药理干预措施.
主要成果:
- 衰老是一个由内部和外部因素影响的可变速度的马赛克过程.
- 微RNA在基因调节中起着关键作用,其重要性得到了2024年诺贝尔奖的认可.
- 太空环境可以加速类似衰老的过程,突出显示环境影响.
- 许多用于神经衰老的候选分子生物标志物需要验证.
结论:
- 表观遗传修饰和非编码RNA是理解大脑衰老和神经退行症的核心.
- 开发验证的分子生物标志物对于诊断和抵消神经衰老至关重要.
- 诸如认知和体育训练等干预措施可以调节衰老率.
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