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在自闭症谱系障碍的valproate诱导大鼠模型中,受损条件的味道厌恶获得的神经分子基础

Tapasya Pal¹, Savannah Harvey¹, Allen S Levine²

¹School of Science, University of Waikato, Hamilton 3216, New Zealand.

|February 26, 2025

概括

模拟自闭症谱系障碍 (ASD) 的老鼠显示有条件的味觉厌恶 (CTA) 减少,表明改变了学习的食物回避. 这表明在ASD中挑性饮食的潜在机制,影响饮食接受.

科学领域:

神经科学是一个神经科学.
行为科学行为科学
遗传学是一个遗传学.

背景情况:

自闭症谱系障碍 (ASD) 的特点是社会,行为和认知异常,通常伴随着食欲失调和限制饮食模式.
患有自闭症的人经常表现出挑的饮食和避免新鲜的食物,这表明味觉和学到的关联在饮食接受中发挥着作用.

研究的目的:

调查假设,有条件的味觉厌恶 (CTA),一种学会避免与疾病相关的食物,在自闭症谱系障碍 (ASD) 中加剧.
与对照大鼠相比,评估CTA大小在酸 (VPA) 自闭症大鼠模型中.

主要方法:

在VPA大鼠和对照大鼠中评估化 (LiCl) 诱导的CTA.
研究了LiCl对神经元激活 (c-Fos) 和与养和关联性学习相关的大脑电路中的基因表达的影响.

主要成果:

与对照组相比,VPA老鼠表现出的CTA,需要更高的LiCl剂量来诱导厌恶.
在对照组中,LiCl影响了下丘脑和杏仁体的c-Fos免疫活性,但在VPA大鼠中没有影响.
在VPA大鼠中观察到与食相关的基因和压力/焦虑基因的差异性基因表达,即使没有LiCl治疗,也会降低一些转录.

结论:

在这种自闭症模型中,VPA大鼠表现出的CTA反应,这表明这种自闭症模型中对食物厌恶的学习机制发生了变化.
这些发现表明LiCl对参与CTA获取的神经回路的影响在与对照对象相比,在模拟ASD的老鼠中有差异.

关键词:

自闭症自闭症是什么厌恶性学习是一种厌恶性学习.有条件的味道厌恶.养行为养行为

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