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在接受体外受精的妇女中发生血栓形成的风险:叙述性审查
Elvira Grandone1,2,3, Victoria Bitsadze1, Jamilya Khizroeva1
1Department of Obstetrics, Gynecology and Perinatal Medicine, The I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya Str. 8-2, 119435 Moscow, Russia.
Journal of clinical medicine
|February 26, 2025
概括
在体外受精 (IVF) 与罕见的血栓形成有关,特别是卵巢过度刺激综合征 (OHSS). 肥胖和晚年母亲年龄等危险因素增加了IVF后早期怀孕期间的血栓栓塞事件.
科学领域:
- 生殖医学 生殖医学
- 血液学 血液学 血液学
- 产科 产科 产科 产科 产科
背景情况:
- 血栓瘤是一种与体外受精 (IVF) 相关的罕见并发症.
- 卵巢过度刺激综合征 (OHSS) 在试管婴儿后显著增加了血栓形成的风险.
- 了解试管婴儿相关血栓的流行病学和病理生理学对于患者的安全至关重要.
研究的目的:
- 审查关于试管婴儿治疗和血栓形成之间的关联的当前文献.
- 专注于这些事件的流行病学数据和潜在的病理生理学.
- 为了确定妇女在试管婴儿期间和之后发生血栓栓塞并发症的关键风险因素.
主要方法:
- 现有科学文献的叙述性审查.
- 对IVF相关血栓发生率的流行病学数据的分析.
- 讨论将试管婴儿,OHSS和血栓形成联系在一起的病理生理机制.
主要成果:
- 血栓瘤是一种罕见的试管婴儿并发症,发病率约为0.2%,OHSS显著增加.
- 动脉血栓,通常是早期的和与OHSS相关的,是罕见的;静脉血栓,虽然更常见,总体上也是罕见的.
- 经常观察到身体上部静脉血栓,在IVF怀孕的头三个月,血栓形成的风险最高.
结论:
- 虽然很少见,但血栓形成是试管婴儿相关的严重并发症,特别是当OHSS存在时.
- 风险因素包括OHSS,血栓性,肥胖,晚年母亲年龄和PCOS增加了血栓栓塞的风险.
- 对这些风险因素的认识和管理对于减轻试管婴儿妇女的血栓形成至关重要.
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