对于他类药物不耐受的患者表现出肌肉强度的减弱,尽管他们接受了降脂疗法
Pierandrea Vinci1, Filippo Giorgio Di Girolamo2, Federica Pellicori1
1Unità Clinica Operativa Clinica Medica, Department of Medical, Surgical and Health Sciences, Faculty of Medicine, University of Trieste and ASUGI, 34149 Trieste, Italy.
Journal of clinical medicine
|February 26, 2025
概括
类他类药物相关的肌肉症状 (SAMS) 与肌肉质量和力量的降低有关,特别是在运动较少的四肢. 这项研究发现,他类药物不耐受与较差的身体组成和肌肉性能有关.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 类他类药物相关的肌肉症状 (SAMS) 是类他类药物治疗的常见不良影响,影响了坚持和心血管风险.
- SAMS,肌肉性能和身体组成之间的确切关系仍然不完全理解.
研究的目的:
- 为了研究对他类药物不耐受 (SI) 和他类药物耐受 (ST) 患者之间的身体组成和肌肉强度的差异.
- 评估他类药物不耐受对肌肉质量和身体组成的长期影响.
主要方法:
- 来自脂质诊所的148名SI和145名年龄/性别匹配的ST患者的回顾性分析.
- 在基线和平均45个月的随访后,评估了心血管风险因素,脂质概况,BMI,身体成分 (BIA) 和肌肉质量 (手握/骨肌肉质量).
主要成果:
- 在SI患者中,基线BMI,胆固醇和甘油三含量都较高. 在随访期间,SI患者的BMI增加,LDL胆固醇持续上升.
- 在随访时,SI患者的脂肪质量百分比较高. 肌肉质量,通过标准化骨肌肉质量的手握强度来评估,在SI患者中明显较低,特别是在非主导的手臂中.
- 基线时肌酸激酶水平的升高在IS患者中仍然较高,在重新挑战后没有重新开始服用他类药物.
结论:
- 在临床上,他类药物不耐受与肌肉质量下降有关,特别是影响不太运动的四肢.
- 这些发现突显了他类药物使用,肌肉健康和身体组成之间的潜在联系,需要进一步调查.
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