三糖/高密度脂蛋白比率和冠状动脉疾病:来自大型单中心研究的结果
Giuseppe De Luca1,2, Matteo Nardin3,4, Antonino Micari1
1Department of Clinical and Experimental Medicine, Division of Cardiology, Policlinico G Martino, University of Messina, 98125 Messina, Italy.
Journal of clinical medicine
|February 26, 2025
概括
高密度脂蛋白 (HDL) 独立地与冠状动脉疾病 (CAD) 的患病率和程度有关. 甘油三和高密度胆固醇 (TG/HDL) 的比率并没有提供超出高密度胆固醇的额外预后信息,用于CAD风险评估.
科学领域:
- 心脏病学 心脏病学
- 脂质代谢 脂质代谢是什么
- 动脉样硬化研究 动脉样硬化研究
背景情况:
- 类药物有效降低LDL-C,但冠状动脉疾病 (CAD) 患者的残留心血管风险仍然存在.
- 低高密度脂蛋白 (HDL) 和高甘油三是已知的心血管风险因素和潜在的治疗点.
- 甘油三与高血糖 (TG/HDL) 的比率越来越多地被审查其在心血管疾病中的作用.
研究的目的:
- 调查甘油三,高血糖和TG/HDL比率与CAD的患病率和程度之间的关联.
- 为了确定TG/HDL比率是否提供了除了CAD中的HDL之外的额外预后信息.
主要方法:
- 在2007年至2018年期间,对5997名接受冠状动脉血管造影的患者进行了回顾性分析.
- 排除接受降甘油三治疗的患者 (PUFA,纤维酸).
- CAD定义为血管狭窄>50%;TG/HDL比率在四分位数中分析.
主要成果:
- TG/HDL比率与各种人口,临床和实验室参数相关.
- 在多变量分析中,只有HDL,而不是TG/HDL比率,是与CAD患病率和程度独立相关的.
- TG/HDL比率没有增加预后价值超出CAD的HDL.
结论:
- 高密度脂蛋白 (HDL) 独立地与冠状动脉疾病 (CAD) 的患病率和程度有关.
- 在考虑高血糖水平时,甘油三与高血糖 (TG/HDL) 的比率并不能为CAD提供增量预后信息.
- 专注于HDL水平可能比CAD患者的TG/HDL比率更具有预后意义.
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