周围动脉疾病中的糖尿病:患病率,并发症和多药性
Mason Baty1, Ritesh Chimoriya1,2, Sophie James1,2
1Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.
Journal of clinical medicine
|February 26, 2025
概括
患有2型糖尿病 (T2DM) 的周围动脉疾病 (PAD) 患者表现出更高的并发症率和多药性. 患有T2DM的PAD患者的失控高血糖是常见的,需要多学科的管理方法.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 血管医学 血管医学
背景情况:
- 周围动脉疾病 (PAD) 患者,特别是2型糖尿病 (T2DM) 患者,面临并发症,组织损失和心血管事件的风险增加.
- 全球T2DM患病率的上升增加了PAD症状患者的发病率,这是澳大利亚研究不足的人口.
- 这项研究描述了患有糖尿病的PAD患者,将其与非糖尿病PAD患者进行比较,以确定患病率,并发症和药物使用情况.
研究的目的:
- 为了确定澳大利亚PAD患者糖尿病的患病率.
- 为了比较患有糖尿病和没有糖尿病的PAD患者之间的主要并发症和药物使用情况.
- 为了检查糖尿病控制和PAD并发症之间的关系.
主要方法:
- 在TEAM-PAD随机对照试验中,对105名PAD参与者的基线数据进行横截面分析.
- 使用了描述性统计数据,流行概率比率和回归分析.
- 从2023年6月到2024年8月期间,从公共诊所,私人外科医生和悉尼一家医院招募了参与者.
主要成果:
- 糖尿病患病率为52.83% (n=56),其中2型糖尿病患者中有29.5% (n=31) 患有无法控制的高血糖症 (HbA1c ≥7%).
- 患有T2DM患者的冠状动脉病史 (POR 2.43) 的几率是两倍,组织损失的几率是三倍以上 (POR 3.39).
- 多药性 (≥5种药物) 在T2DM患者中显著高 (POR 10.8),影响了这一亚组的96.4%.
结论:
- 在PAD患者中,糖尿病患病率和相关并发症高于此前估计的.
- 在PAD患者中管理糖尿病和多药性治疗存在重大挑战.
- 建议采用多学科的方法,以潜在地改善患者的治疗结果.
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