营养补充剂和益生菌在接受血液透析的患者的精神病菌保护:一项随机试验
Eric Climent1, Francisco Hevilla2,3,4, Marina Padial2,3,4
1Departamento de Biotecnología, Universitat Politècnica de València, 46022 Valencia, Spain.
Nutrients
|February 26, 2025
概括
使用益生菌的口服营养补充剂显著改善了血液透析患者的心理健康,减少了血液透析患者的抑郁症. 这种干预也对肠道微生物群产生了积极的影响,并降低了肠道透性标记物.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 胃肠病学 胃肠病学
- 精神病学是一个精神病学.
背景情况:
- 营养不良的血液透析患者表现出高的抑郁和焦虑率.
- 肠道透性和肠道失生症与抑郁症的病理生理学有关.
研究的目的:
- 评估口服营养补充剂 (ONS) 与益生菌混合物对血液透析患者的微生物群,肠道透性和抑郁症的影响.
主要方法:
- 一个随机试验与三个组:控制,ONS与安慰剂,和ONS与益生菌.
- 收集了6个月的血液和便样本.
- 测量了生物标志物 (松素,LPS,BDNF),便微生物组和抑郁/焦虑症状 (HADS,SF12-MH).
主要成果:
- 益生菌组表现出稳定的脂聚糖化物 (LPS) 水平和降低的大脑衍生神经营养因子 (BDNF).
- 在益生菌组中,抑郁症得分 (HADS-D) 和心理健康生活质量 (SF12-MH) 显著改善.
- 微生物组的变化包括减少了Akkermansia和增加了Barnesiella的丰度.
结论:
- 组合的ONS和益生菌可能会降低营养不良的血液透析患者的肠道透性标记物.
- 这种干预表明了改善抑郁症状和生活质量的潜力.
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