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用植物丰富的食补充剂降低血LDL胆固醇:是还是不是?

Frans Stellaard¹, Dieter Lütjohann¹

¹Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, 53127 Bonn, Germany.

|February 26, 2025

概括

升高的LDL-C会增加动脉样硬化风险. 虽然他类药物和ezetimibe降低了LDL-C,但高摄入的植物可能会矛盾地增加动脉样硬化风险,特别是在正常胆固醇水平的个体中.

科学领域:

生物化学生物化学
心血管医学心血管医学
营养科学营养科学

背景情况:

高血低密度脂蛋白胆固醇 (LDL-C) 是动脉样硬化和心血管疾病的重要危险因素.
胆固醇的LDL-C水平受到胆固醇合成,吸收和恒温的影响.
药物干预措施,如他类药物和ezetimibe有效降低LDL-C.

研究的目的:

评估植物醇和植物醇补充剂对胆固醇水平和动脉样硬化风险的影响.
为了比较植物醇与制药LDL-C降低剂的疗效和安全性.
调查与增加植物摄入量相关的潜在风险,特别是在正常或略高LDL-C的个体中.

主要方法:

对植物/植物的有效性和安全性的科学证据的审查.
对植物醇 (每天2-3克) 抑制胆固醇吸收的分析,导致~10%的LDL-C降低.
对影响植物醇反应和风险的遗传因素 (NPC1L1,ABCG5/G8) 的检查.

主要成果:

植物醇/植物醇通过抑制胆固醇吸收,将LDL-C降低约10%.
高剂量的植物醇摄入可能与增加动脉样硬化风险有关.
患有正常或轻微升高的LDL-C的人可能不会从植物中受益,并且由于缺乏补偿性LDL-C降低,可能面临更高的风险.

结论:

植物补充剂提供适度的LDL-C降低,但携带动脉样硬化的潜在风险,特别是在正常胆固醇的人.
植物的风险-益处概况取决于基线LDL-C水平和个体遗传因素.
建议谨慎使用广泛的植物,特别是在健康人群中或那些控制良好的LDL-C的人群中.

关键词:

动脉样硬化动脉样硬化坎普斯特罗尔可以使用.心血管疾病心血管疾病胆固醇胆固醇胆固醇是一种植物醇是一种植物醇.赛托斯醇 (Sitosterol) 是一种醇.

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