使用不同方法计算的氧化平衡得分及其与结肠直肠癌风险的关联
Fangting Lin1, Ruolin Zhou1, Qingjian Ou2
1Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
Nutrients
|February 26, 2025
概括
对氧化平衡得分 (OBS) 的更高遵守,这是饮食和生活方式氧化压力的衡量标准,与降低结直肠癌 (CRC) 风险有关. OBS-1显示出最强的保护性关联.
科学领域:
- 营养流行病学 营养流行病学
- 预防癌症 预防癌症
- 氧化压力研究研究 氧化压力研究
背景情况:
- 氧化平衡评分 (OBS) 量化了导致氧化应激的饮食和生活方式因素.
- 关于OBS与结直肠癌 (CRC) 风险之间的关联存在有限的研究,计算方法各异.
- 了解这种关系对于制定有针对性的预防策略至关重要.
研究的目的:
- 调查不同氧化平衡得分 (OBS) 计算方法与结直肠癌 (CRC) 风险之间的关联.
- 为了比较四种不同的OBS计算方法在CRC风险方面的表现.
- 探索OBS对CRC风险的潜在非线性关系和子组影响 (性别,瘤部位).
主要方法:
- 在中国广州进行了一项病例控制研究,包括2799例CRC病例和匹配的对照.
- 用四种不同的方法计算氧化平衡得分 (OBS).
- 使用无条件后勤回归和受限立方线来分析OBS和CRC风险之间的关联,并进行分层和子组分析.
主要成果:
- 所有四个计算的氧化平衡得分 (OBSs) 都与降低结直肠癌 (CRC) 风险有关.
- 在所有四种方法中,更高的OBS遵守率始终与较低的CRC风险有关.
- OBS-1显示了与CRC风险的最强的反向关联 (OR=0.42,95%CI:最高四分位数的0.35-0.50).
- 观察到线性关系,没有发现显著的非线性关联 (所有p-非线性>0.05).
- 负面关联在不同性别和结肠癌和直肠癌亚型中一致.
结论:
- 所有评估的氧化平衡得分 (OBSs) 与结直肠癌 (CRC) 风险相反相关.
- 氧化平衡得分,特别是OBS-1,显示了评估与生活方式和饮食相关的CRC风险的有价值工具的潜力.
- 需要进一步的研究来验证OBS计算方法及其在癌症预防中的临床实用性.
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