肠道微生物群概况和婴儿的功能性胃肠道疾病:一个纵向研究
Alexandru Cosmin Pantazi1,2, Cristina Maria Mihai1,2, Ancuta Lupu3
1Faculty of Medicine, "Ovidius" University of Constanta, 900470 Constanta, Romania.
Nutrients
|February 26, 2025
概括
患有功能性胃肠道疾病的婴儿表现出肠道失调,肠道中含有较少的有益细菌,如Lactobacillus和Bifidobacterium. 剖腹产和人工养增加了FGID风险和微生物失衡.
科学领域:
- 微生物学 微生物学
- 儿科 儿科 儿科
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群在胃肠道功能和功能性胃肠道疾病 (FGIDs) 的发展中起着至关重要的作用.
- FGID在婴儿中很常见,包括婴儿结肠,功能性便秘,胃食道逆流和功能性腹等疾病.
研究的目的:
- 为了研究被诊断患有FGIDs的婴儿的肠道微生物群组成.
- 分析患有FGID的婴儿微生物群,年龄,环境因素和临床症状之间的关系.
主要方法:
- 研究了一组134名婴儿,其中82名患有FGID (分为四个子组) 和52名健康对照,全部使用罗马四号标准进行评估.
- 对便样本进行细菌学分析,以确定肠道微生物群的组成.
主要成果:
- 患有FGIDs的婴儿表现出肠道失生症,其特征是酸化细菌 (乳酸菌,双菌,菌) 的减少和蛋白质分解细菌 (Enterobacteriaceae,Klebsiella,Escherichia coli) 的增加.
- 在剖腹产或人工养的婴儿中观察到FGID和肠道失调的更高发病率.
结论:
- 肠道微生物组成中的酸化和蛋白质溶解之间的不平衡是婴儿期功能性胃肠道疾病发展的潜在关键因素.
- 环境因素,如分娩方式和养方法显著影响肠道微生物群和婴儿的FGID发生.
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