结构性特征和抗痛风性病 聚糖的潜力 来自中国虫 (Atractylodes chinensis)
Molecules (Basel, Switzerland)
|February 26, 2025
概括
来自Atractylodes chinensis (ACP) 的多糖有效地通过减少炎症和损伤来治疗痛风性病 (GN). 最强效的部分,ACP-60-A,通过抑制NLRP3炎症酶通路而起作用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 痛风性病 (GN) 是高尿血症的严重并发症,其特征是炎症和损伤.
- 传统的中国医药,如阿特拉提洛德斯chinensis (DC.) 科伊兹提供了对GN的潜在治疗剂.
- 了解传统药物的活性成分和机制对于开发新疗法至关重要.
研究的目的:
- 为了提取和表征来自阿特拉提洛德 (Atractylodes chinensis,简称ACP) 的多糖类.
- 评估ACP及其微分的抗痛风病 (GN) 活性,体内和体外.
- 阐明ACP抗GN作用的结构基础和分子机制.
主要方法:
- 使用DEAE-52纤维素列染色学提取和分离ACP.
- 在体内研究使用Sprague-Dawley大鼠诱导GN,评估生化标志物 (尿酸,肌,BUN) 和NLRP3表达.
- 使用HK-2细胞进行体外研究,并阐明活性分量的结构 (单糖化合物组成,甘油酸链接).
主要成果:
- 在GN大鼠中,ACP治疗显著降低了血清尿酸,肌素和BUN水平.
- 在ACP分子中,特别是ACP-60-A (9.18 kDa),在体外和体内表现出显著的抗转基因活性.
- 主要由果糖和葡萄糖组成的ACP-60-A具有特定的葡萄糖链接,通过降低NLRP3,ASC和Caspase-1的调节来抑制NLRP3炎症酶途径.
结论:
- ACP具有显著的抗痛风病活性,通过抑制NLRP3炎症体信号通路进行介导.
- 低分子量,特异性单糖化合物组成和ACP-60-A独特的糖结构有助于其卓越的疗效.
- 作为治疗痛风性病的潜在治疗剂,ACP-60-A具有前景,需要进一步研究以进行净化和修改.
相关概念视频
Glycosaminoglycans
4.7K
Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
4.7K
Proteoglycans
3.9K
Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
3.9K
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
142
α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
Acarbose and miglitol are...
142
Oligosaccharide Assembly
2.8K
Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
Multiple sugar molecules that may or may...
2.8K
Protein Glycosylation
6.7K
Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
Glycosylation occurs in...
6.7K
Cellulose and Pectic Polysaccharides
3.5K
Every plant cell has a cell wall that protects the cell, provides structural support, and gives the cell shape. Cellulose, the main structural component of the plant cell wall, makes up over 30% of plant matter. It is the most abundant organic compound on earth. Cellulose is an unbranched polysaccharide composed of linear chains of glucose molecules linked by β (1→4) glycosidic bonds.
As a cell matures, its cell wall specializes according to its type. For example, the...
As a cell matures, its cell wall specializes according to its type. For example, the...
3.5K


