从废物到价值:从橄叶提取生物活性提取物的可溶性和溶解增强使用波洛克萨默
Muhammad Wasim1, Maria Camilla Bergonzi1
1Department of Chemistry "Ugo Schiff" (DICUS), University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy.
Molecules (Basel, Switzerland)
|February 26, 2025
概括
橄叶生物废物被转化为有价值的三烯和多烯提取物. 固体分散显著提高了这些化合物的可溶性和溶解性,为制药应用铺平了道路.
科学领域:
- 生物技术是生物技术.
- 绿色化学 绿色化学
- 制药科学 制药科学
背景情况:
- 欧盟每年产生超过25亿的废物,需要循环经济方法.
- 橄叶生物废物带来环境和经济挑战,但含有有价值的化合物.
- 橄叶废弃物的利用可以产生具有制药,食品和化品潜力的提取物.
研究的目的:
- 通过提取三烯和多来利用橄叶生物废物.
- 使用Poloxamer-188和Poloxamer-407将三烯提取物 (TTP70) 制成固体分散物.
- 评估这些固体分散对TTP70.0.的可溶性,溶解和透性的影响.
主要方法:
- 使用制方法与P188和P407在不同重量比率 (1:1, 1:2, 1:5) 上制备了TP70的固体分散物.
- 评估了TTP70的可溶性,溶解概况和体外被动透性 (PAMPA).
- 固体分散物与多提取物 (OPA40) 结合,并封装成硬凝囊.
主要成果:
- 水友性载体 (P188,P407) 和所有测试的重量比都显著提高了TTP70的溶解性和三烯溶解.
- PAMPA实验证实了从固体分散中提升的三二烯的被动透.
- 复合制剂证明了对三烯和多醇的溶解得到了改善.
结论:
- 固体分散技术有效地提高了橄叶提取物中疏水性三烯的可溶性,溶解性和透性.
- 将橄叶提取物制成固体分散剂,然后封装为开发口服剂型提供了可行的策略.
- 这种方法有助于废物利用和开发各种行业的新生物活性化合物.
相关概念视频
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