开发和验证用于预测尿路感染糖尿病患者败血症风险的诺米克图
Hua-Qiao Tan1,2, Xiang-Jie Duan3, Wan Qu4
1Department of Epidemiology, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China.
Medicina (Kaunas, Lithuania)
|February 26, 2025
概括
患有尿路感染 (UTI) 的糖尿病患者面临着败血症的高风险. 这项研究开发了一种使用9个因素预测这些患者败血症风险的诺米克图,以帮助临床管理.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 糖尿病学 糖尿病学
- 关键护理医学 关键护理医学
背景情况:
- 尿路感染 (UTI) 是糖尿病患者经常出现的并发症.
- 糖尿病患者的尿路感染是败血症的重要原因.
- 在这个人群中开发出对败血症的预测工具至关重要.
研究的目的:
- 开发和验证用于预测患有尿路感染 (DPUTIs) 的糖尿病患者中败血症风险的诺米克图.
- 确定DPUTIs中败血症风险的独立预后因素.
主要方法:
- 使用MIMIC-IV数据库中的数据进行了回顾性观察研究.
- 基于LASSO和多变量逻辑回归的编号图的开发.
- 使用AUC,NRI,IDI,校准曲线和DCA.验证名录的验证.
主要成果:
- 确定了9个独立的预后因素:尿液红血细胞分类,尿液白血细胞分类,血糖,年龄,温度,白血细胞,SOFA评分,淋巴细胞和血红素.
- 命名图表显示了强大的区分和良好的校准.
- 决策曲线分析表明了有利的临床效用.
结论:
- 开发的诺米图有效预测DPUTI中的败血症风险.
- 这种工具可以帮助临床医生优化患有尿路感染的风险糖尿病患者的管理.
- 为早期干预和风险因素管理提供基于证据的支持.
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