吸烟对高风险HPV阳性女性宫组织病理变化的影响:一项匹配的病例对照研究
İlkan Kayar1, Goksu Goc2, Ferhat Cetin3
1Department of Obstetrics and Gynecology, Osmaniye State Hospital, 80000 Osmaniye, Turkey.
Medicina (Kaunas, Lithuania)
|February 26, 2025
概括
吸烟显著增加了高风险HPV类型的女性异常宫组织病理的风险. 戒烟对于消除HPV感染和预防宫瘤变化至关重要.
科学领域:
- 妇科 妇科 妇科 妇科
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 高风险的人类乳头瘤病毒 (HPV) 类型16和18是导致宫异常的常见原因.
- 吸烟是众所周知的各种癌症的风险因素,但它对HPV阳性女性宫组织病理学的具体影响需要进一步阐明.
研究的目的:
- 评估吸烟对患有高风险HPV型16和18的女性宫组织病理学的影响.
- 根据吸烟包年进行宫组织病理的风险分析.
主要方法:
- 一项涉及1048名高风险HPV阳性女性 (25-65岁) 的病例控制研究,分为吸烟者和非吸烟者.
- 样品的组织病理学检查从结肠镜评估和内宫皮切割 (ECC).
- 包括ROC分析在内的统计分析,以确定异常基因病理学的包年值.
主要成果:
- 吸烟者表现出异常宫细胞学的比率显著高 (p < 0.001) 和正常结果的比率较低 (14%对29%).
- 吸烟者在结肠镜活检和ECC (p < 0.001) 中出现高度状内皮病变 (HGSIL) 和宫内皮病变 (CIN) 的比率较高.
- 异常组织病理的发病率显著高于20个包年 (colposcopy) 和13个包年 (ECC) 的个体.
结论:
- 长期和过度吸烟显著加剧HPV的持续性和进展,影响子宫子宫的瘤变化.
- 戒烟对于女性来说至关重要,以消除HPV感染并降低宫瘤变化的风险.
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