作为移民人口中感染标志物的结核指数病例暴露时间
Sofia Godoy1,2, Miquel Alsedà1,3, Ignasi Parrón3
1Institut de Recerca Biomédica de Lleida (IRBLleida), Universitat de Lleida, 25198 Lleida, Spain.
Pathogens (Basel, Switzerland)
|February 26, 2025
概括
移民中潜伏结核病感染 (LTBI) 的风险随着感染性结核病例的暴露时间的延长而增加. 这表明最近的LTBI可能与最近的风险持续时间有关.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 对结核病 (TB) 指数病例的暴露时间是最近潜伏结核病感染 (LTBI) 风险的潜在指标.
- 了解移民人口中的LTBI风险对于有针对性的公共卫生干预至关重要.
研究的目的:
- 根据他们接触肺结核指数病例的暴露时间,评估移民接触者中潜在结核感染 (LTBI) 的风险.
主要方法:
- 在加泰罗尼亚进行了一项为期30个月 (2019-2021) 的研究,评估了肺结核病移民接触者中LTBI的患病率.
- 通过结核素皮肤测试和/或干扰素马释放测试来诊断LTBI.
- 统计分析涉及调整的赔率比率 (aOR) 和95%置信区间 (CI) 来识别相关变量.
主要成果:
- 在移民接触者中,LTBI的总体患病率为37.4% (939/2509).
- 男人 (40.6%) 的LTBI患病率高于女性 (33.5%),与5岁以下儿童 (12.2%) 相比,在所有年龄组中都增加.
- 与暴露时间显著相关的LTBI风险:≥6小时/天 (aOR=2.0) 和<6小时/天,但≥6小时/周 (aOR=1.6) 与<6小时/周暴露相比风险增加.
结论:
- 增加对结核病指数病例的暴露时间与移民接触者中较高的LTBI风险有关.
- 这一发现凸显了考虑近期暴露持续时间的重要性,以确定移民中近期的LTBI.
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