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在接受白内障手术的患者中,结膜微生物群和抗生素敏感性模式的表征
Aldo Vagge1,2, Filippo Lixi3, Diego Ponzin4
1Eye Clinic of Genoa, Policlinico San Martino, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, 16132 Genoa, Italy.
Microorganisms
|February 26, 2025
概括
白内障手术患者经常携带潜在的致病细菌,其中葡萄状菌是最常见的. 莫西弗洛克萨辛和氨基醇对这些细菌具有很高的有效性,与托布拉米辛和奥夫洛克萨辛不同.
科学领域:
- 眼科和微生物学
- 抗微生物耐药性 抗微生物耐药性
- 手术前的眼睛健康
背景情况:
- 白内障手术需要一个无菌的眼睛环境,以防止术后感染.
- 了解结膜菌群的患病率和抗生素敏感性对于有效的预防至关重要.
- 之前的研究表明,在接受眼科手术的患者中,细菌菌群和耐药性模式的变化.
研究的目的:
- 对于预定要进行白内障手术的患者的结膜上存在的细菌菌群的特征.
- 为了确定分离的细菌对常用的局部抗生素的体外易感性.
主要方法:
- 在接受抗生素治疗之前接受老年性白内障手术的44名患者收集了结膜片.
- 使用选择性培养介质和微扫描特种ID面板进行了细菌鉴定.
- 对9种不同的抗生素进行的抗菌敏感性测试使用了Kirby-Bauer磁盘扩散方法.
主要成果:
- 很大一部分患者 (38.6%) 存在潜在的病原菌群,其中葡萄球菌是最常见的分离物 (例如,S. epidermidis,S. intermedius,S. aureus).
- 甲素耐药黄金葡萄球菌 (MRSA) 和表皮葡萄球菌 (MRSE) 分别在8.0%和6.8%的分离物中检测到.
- 莫西弗洛克萨辛和氨基醇在体外表现出极好的敏感性 (83-100%) 对所有测试的阳性和阴性细菌,而托布拉米辛和奥夫洛克萨辛显示敏感性降低.
结论:
- 预计要进行白内障手术的眼睛中有相当一部分被潜在的致病细菌所定居,主要是白内障菌.
- 由于MRSA和MRSE的出现,强调了监测抗生素耐药性的重要性.
- 莫西弗洛克萨辛和氨基醇对普遍存在的结膜菌群是有效的,而目前的敏感性数据表明,在这种患者群体中使用托布拉米辛和奥夫洛克萨辛应该谨慎使用.
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