在口腔伤愈合过程中发生的微生物变化
Steven L Goudy1,2,3, Heath L Bradley1,2, Camilo Anthony Gacasan2
1Department of Otolaryngology, Emory University, Children's Healthcare of Atlanta, Atlanta, GA 30329, USA.
Microorganisms
|February 26, 2025
概括
小鼠的耳鼻 (ONF) 破坏了口腔微生物群,导致病原体繁殖,可能阻碍愈合. 针对ONF治愈的治疗方法可以恢复微生物组的平衡,并防止病原体过度生长.
科学领域:
- 微生物学 微生物学
- 伤口愈合 治愈 伤口愈合
- 口腔健康 口腔健康
背景情况:
- 口腔微生物组是复杂的,与全身健康有关.
- 表面的口腔伤口能有效地愈合,但耳鼻管 (ONFs) 是一个愈合的挑战.
- ONF通常是裂口口腔手术的结果.
研究的目的:
- 在小鼠中创建ONF后调查口腔微生物组的变化.
- 了解ONF对伤口愈合和微生物组成的影响.
主要方法:
- 具有诱导ONFs的小鼠口腔微生物组的特征变化.
- 在ONF注射前服用口服抗生素,以评估微生物和治疗影响.
主要成果:
- ONF的创建减少了口腔微生物群的多样性,并导致了*Enterococcus faecalis*,*Staphylococcus lentus*和*Staphylococcus xylosus*的繁殖.
- 在ONF注射之前的抗生素治疗减少了微生物多样性,并防止了病原体的繁殖,但没有改善ONF的愈合.
- 一个ONF的存在创造了一个带有机会性病原体繁荣的异生性口腔微生物组.
结论:
- 在小鼠中,ONFs诱导口腔失生症和机会性病原体的繁殖,可能阻碍愈合.
- 加快ONF愈合的治疗策略可以恢复口腔微生物群的多样性并控制病原体的过度生长.
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