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主体遗传学和益生菌对猪生长性能的联合贡献

Jinyi Han¹, Mingyu Wang¹, Shenping Zhou²

¹College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450002, China.

|February 26, 2025

概括

主体遗传和肠道益生菌相互作用,影响猪生长. 像Coprococcus和Ruminococcaceae这样的特定微生物与体重和BMI有关,宿主基因会影响它们的数量.

科学领域:

动物遗传学动物遗传学
微生物组研究微生物组研究
畜牧科学畜牧科学畜牧科学

背景情况:

肠道益生菌影响宿主生长,但与宿主遗传学的相互作用尚未得到充分探索.
肠道微生物群的组成受到各种因素的影响,影响生长特征,如体重和BMI.

研究的目的:

为了研究宿主遗传,肠道微生物群和云黑猪生长表现之间的关系.
识别特定的微生物种群和影响生长特征的宿主遗传因素.

主要方法:

收集了便和组织样本,以及来自193头云龙黑猪的表型数据.
使用50K SNP BeadChip进行全基因组测序和基因型鉴定.
利用了微生物组范围的关联研究 (MWAS) 和微生物组范围的遗传关联研究 (MGWAS).

主要成果:

四个关键的微生物种群 (Coprococcus, Blautia, Ruminococcaceae, RF16) 与体重和BMI有显著的相关性.
科普罗可可和鲁米诺可可科科 (Ruminococcaceae) 显示出与宿主基因组变异的显著关联.
确定了四种与三种候选基因 (INPP4B,SCOC,PABPC4L) 相关的显著单核酸多态 (SNPs) 影响微生物丰富性.

结论:

主体遗传学和肠道益生菌共同促进了猪的宿主生长特征.
为开发有针对性的繁殖策略提供了洞察力,以提高牲畜表现.
强调在动物育种中考虑宿主微生物组与遗传学的相互作用的重要性.

关键词:

这就是为什么BMI是BMI.在MGWAS中使用的MGWASs 我们的肠道微生物群.增长的成长的表现.猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪猪

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