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Updated: May 25, 2025

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

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遗传变异对普雷加巴林药理动力学和安全性的影响

Sofía Calleja1, Andrea Rodríguez-López1, Dolores Ochoa1

  • 1Clinical Pharmacology Department, Hospital Universitario de La Princesa, Faculty of Medicine, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IIS-Princesa), 28006 Madrid, Spain.

Pharmaceuticals (Basel, Switzerland)
|February 26, 2025
PubMed
概括

遗传变异,如NAT2缓慢的乙化剂,可能会略微影响普雷加巴林 (普雷加巴林) 药理动力学,但性差异的暴露对预测药物不良反应更为关键,而不是遗传学.

关键词:
药物遗传学 药物遗传学药物动力学 药物动力学普雷加巴林 (Pregabalin) 是一种药物.在安全方面,安全是安全的.

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Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA11:35

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