微针的应用用于高分子量德克斯穿透口腔粘膜
Adriana Fantini1, Andrea Delledonne2, Luca Casula3
1ADDRes Lab, Department of Food and Drug, University of Parma, Parco Area delle Scienze 27/a, 43124 Parma, Italy.
Pharmaceuticals (Basel, Switzerland)
|February 26, 2025
概括
可溶性微针有效地提高了通过粘膜组织的高分子量德克斯的透. 更长的可溶性微针 (500和800微米) 显著加快了这些分子的快速运输.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 组织工程是组织工程.
背景情况:
- 口腔粘膜对高分子量药物的输送构成障碍.
- 微针技术为增强跨粘膜药物透提供了潜力.
研究的目的:
- 为了评估不同微针策略的有效性,通过口腔粘膜传递高分子量模型分子.
- 为了比较固体和可溶性微针在增强透性的性能.
主要方法:
- 研究的不钢微针 (500微米) 用于组织预处理.
- 使用的可溶性微针 (150,500,800μm) 由聚烯和光标记德克斯 (FDs) 制成.
- 采用猪食道上皮作为口腔粘膜模型.
主要成果:
- 可溶性微针显著促进了高分子量 (70和150kDa) 的FD的运输.
- 运输效率与可溶性微针长度相关,500微米是最小有效长度.
- 与可溶性微针相比,固体微针的预处理导致透开始较慢.
结论:
- 500和800微米的可溶性微针可通过粘膜组织快速运输高分子量德克斯.
- 通过多光子显微镜证实了微针诱导的孔和组织内德克斯的存在.
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