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Updated: May 25, 2025

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一种机械化学合成的皮拉津胺-乙-酸-性酸混合物的热力学和结构特征

Luís H S Queiroz1, Mateus R Lage1, Clenilton C Dos Santos2

  • 1Programa de Pós-Graduação em Ciência dos Materiais (PPGCM), Centro de Ciências de Imperatriz (CCIM), Universidade Federal do Maranhão (UFMA), Imperatriz 65900-410, Maranhão, Brazil.

Pharmaceuticals (Basel, Switzerland)
|February 26, 2025
PubMed
概括

通过绿色机械化学合成了一种新型药物-药物欧性混合物 (DDEM) 的乙酸和金胺. 这种可持续的方法提高了药物的溶解性和溶解性,显示了改善药物输送系统的潜力.

关键词:
DFT计算的计算方法乙撒利酸 (ASA) 是一种药物药物性混合物 (DDEM) 是一种药物性混合物.绿色化学 是一种绿色化学.机械化学 机械化学皮拉津胺 (PZA) 是一种结核病是一种肺结核病.

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Basicity of Heterocyclic Aromatic Amines01:25

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Heterocyclic amines, where the N atom is a part of an alicyclic system, are similar in basicity to alkylamines. Interestingly, the heterocyclic amine having a nitrogen atom as part of an aromatic ring has much less basicity than its corresponding alicyclic counterpart. For this reason, as presented in Figure 1, piperidine (pKb = 2.8) is significantly more basic than pyridine (pKb = 8.8).
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