相关实验视频

Updated: Jul 7, 2026

OLIgo Mass Profiling OLIMP of Extracellular Polysaccharides

OLIgo Mass Profiling OLIMP of Extracellular Polysaccharides

Published on: June 20, 2010

从Ganoderma leucocontextum子中提取多糖的优化和生物活性

Siying Peng^1,2, Yanghui Ou², Yali Zhang²

¹School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China.

Pharmaceuticals (Basel, Switzerland)

|February 26, 2025

概括

来自Ganoderma leucocontextum子的一种新型多糖,GLSP-A1,通过减少氧化应激和炎症,显示出显著的抗衰老特性. 这种天然化合物有望在食补充剂中用于对抗衰老效应.

科学领域:

生物化学生物化学
药理学药理学是指药理学的学科.
老年学是一门学科.

背景情况:

氧化应激是衰老的关键因素,天然的多糖因其抗氧化和抗衰老的潜力而闻名.
来自西藏高原的一种罕见的,Ganoderma leucocontextum,具有显著的生物活动,但其子仍未得到充分研究.
关于Ganoderma leucocontextum子的研究有限,这突出了了解它们的治疗应用的差距.

研究的目的:

为了从Ganoderma leucocontextum子中提取和表征一个多糖.
为了评估分离的多糖的抗炎和抗衰老作用.
为了探索Ganoderma leucocontextum子多糖体作为天然抗衰老剂的潜力.

主要方法:

从Ganoderma leucocontextum子中提取多糖 (GLSP) 使用三相分区 (TPP) 方法.
优化采掘条件使用盒子-Behnken设计 (BBD) 以提高产量和效率.
用物理化学分析 (分子量,FTIR,单糖化合物组成,SEM) 净化GLSP-A1通过列色谱和表征.

主要成果:

优化的TPP提取产生了GLSP,从中净化了GLSP-A1.
在实验室中,GLSP-A1通过降低干白素-6和干白素-1β的调节来表现出抗炎活性.
使用Caenorhabditis elegans的体内研究表明GLSP-A1减少了反应性氧物种和脂素积累,表明抗衰老作用.

结论:

来自Ganoderma leucocontextum子的多糖体GLSP-A1具有显著的体外抗炎特性.
GLSP-A1通过减轻氧化应激和年龄颜料积累,在体内表现出显著的抗衰老作用.
这些发现支持GLSP-A1作为抗衰老食补充剂的功能成分的潜力.

关键词:

甘菌 leucocontextum 子子抗衰老的抗衰老的这是一种抗炎症药物.聚糖是一种多糖.三相分区是三相的分区.

更多相关视频

Automated Modular High Throughput Exopolysaccharide Screening Platform Coupled with Highly Sensitive Carbohydrate Fingerprint Analysis

Automated Modular High Throughput Exopolysaccharide Screening Platform Coupled with Highly Sensitive Carbohydrate Fingerprint Analysis

Published on: April 11, 2016

High-throughput Screening of Carbohydrate-degrading Enzymes Using Novel Insoluble Chromogenic Substrate Assay Kits

High-throughput Screening of Carbohydrate-degrading Enzymes Using Novel Insoluble Chromogenic Substrate Assay Kits

Published on: September 20, 2016

相关概念视频

Sugars as Energy Storage Molecules

Sugars as Energy Storage Molecules

Sugar (a simple carbohydrate) metabolism (chemical reactions) is a classic example of the many cellular processes that use and produce energy. Living things consume sugar as a major energy source because sugar molecules have considerable energy stored within their bonds. Consumed carbohydrates have their origins in photosynthesizing organisms like plants. During photosynthesis, plants use the energy of sunlight to convert carbon dioxide gas into sugar molecules, like glucose. Because this...

Bioreactor Controls-III

Bioreactor Controls-III

Strain improvement is a foundational strategy in industrial microbiology aimed at maximizing microbial productivity, particularly because natural isolates typically yield commercially valuable products in very low concentrations. Although optimizing the culture medium and environmental conditions can improve yields, these adjustments are inherently limited by the organism’s genetic potential. As a result, the focus shifts toward genetic modifications to enhance biosynthetic capacity. The...

Production of Organic Acids

Production of Organic Acids

Lactic acid, an important organic acid extensively applied in food, pharmaceutical, and biodegradable polymer industries, is primarily produced via microbial fermentation. This method is favored over chemical synthesis due to its environmental sustainability and capacity for enantiomerically pure product formation. Among various microbial processes, the fermentation of starch-based substrates stands out due to the abundance and renewability of raw materials like corn and potatoes.Hydrolysis of...