在平板电脑压缩过程中应用数字模拟的进步
Zhe Li1, Haolong Xiong1, Qiong Li1
1Key Laboratory of Modern Preparation of TCM of Ministry of Education, Institute for Advanced Study, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Pharmaceutics
|February 26, 2025
概括
数字模拟通过揭示内部微观行为,促进了对制药粉末紧缩的理解. 这种技术对于分析和控制平板电脑制造工艺至关重要.
科学领域:
- 制药工程 制药工程
- 材料科学 材料科学 材料科学
- 计算力学 计算力学 计算力学
背景情况:
- 药片制造依赖于粉末缩,这种过程的内部应力和微观结构变化仍然不太清楚.
- 目前的研究正在从宏观观测转向对压缩行为的微观分析.
- 了解粉末流动和压缩对于有效的药片生产和质量控制至关重要.
研究的目的:
- 审查数值模拟技术在制药粉末压缩中的应用.
- 在数值模拟中讨论常用的接触模型和构成方程.
- 确定参数校准的挑战和当前研究的局限性.
主要方法:
- 使用数字模拟技术,如离散元素方法 (DEM),有限元素方法 (FEM) 和计算流体动力学 (CFD).
- 分析粉末压缩过程中的内部应力状态和微观结构变化.
- 审查与粉末行为相关的接触模型和构成方程.
主要成果:
- 数字模拟使我们能够转向了解粉末在压缩过程中的微观行为.
- 该审查涵盖了各种模拟技术及其在压缩过程中的应用.
- 强调了粉末参数校准和当前研究局限性的困难.
结论:
- 数字模拟是分析制药粉末紧缩的强大工具.
- 模拟技术的进步将推动医学和其他领域的进一步研究和应用.
- 由于其有效性,预计数字模拟将越来越多地采用.
相关概念视频
Downsampling
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When considering a sampled sequence with zero values between sampling instants, one can replace it by taking every N-th value of the sequence. At these integer multiples of N, the original and sampled sequences coincide. This process, known as decimation, involves extracting every N-th sample from a sequence, thereby creating a more efficient sequence.
The Fourier transform of the decimated sequence reveals a combination of scaled and shifted versions of the original spectrum. This...
The Fourier transform of the decimated sequence reveals a combination of scaled and shifted versions of the original spectrum. This...
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Upsampling
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Managing signal sampling rates is essential in digital signal processing to maintain signal integrity. A decimated signal, characterized by a reduced frequency range due to its lower sampling rate, can be upsampled by inserting zeros between each sample. This upsampling process expands the original spectrum and introduces repeated spectral replicas at intervals dictated by the new Nyquist frequency. To refine this zero-inserted sequence, it is passed through a lowpass filter with a cutoff...
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