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在英国农场工人中高Mycobacterium bovis暴露但低IGRA阳性

Amy Thomas¹, Alice Halliday², Genevieve Clapp¹

¹Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Zoonoses and public health

|February 26, 2025

概括

在英格兰,暴露于结核病感染牛的个体中发现了有限的潜伏结核病感染 (LTBI). 高风险农民需要优先参与未来的牛结核病 (TB) 预防战略.

科学领域:

兽医医学兽医医学兽医医学
公共卫生公共卫生
传染性疾病传染性疾病

背景情况:

由Mycobacterium bovis (M. bovis) 引起的动物性结核病 (TB) 影响了英国的人类,在1999年至2021年期间报告了505例病例.
了解暴露于结核病感染牛的个体中M. bovis感染的流行率对于公共卫生干预至关重要.

研究的目的:

估计英格兰暴露于结核病感染牛的人群中M. bovis感染的流行率.
在这种高暴露人群中识别与潜在结核病感染 (LTBI) 相关的风险因素.

主要方法:

一项回顾性队列研究与英格兰西南部的英国农业社区共同开发.
参与者填写了关于特征和农业实践的问卷;与群体测试数据的联系将结核病暴露风险分类为 (低,中,高).
干扰素玛释放试验 (IGRA) 确定了LTBI状态,与问卷数据联系在一起.

主要成果:

招募了90名参与者 (农民,农场工人,兽医专业人员).
接触M. bovis的发生是通过与受感染的牛和生牛奶消费的直接接触.
在所有参与者中观察到IGRA阳性率为1.1%,在高暴露组中为4.0%;只有一个高风险参与者是IGRA阳性.

结论:

在长期暴露于结核病感染牛的个体中发现了有限的LTBI.
确定了一个特定的高风险农民群体,以优先考虑未来的参与和有针对性的干预.

关键词:

英格兰英格兰英格兰英格兰.这里是牛群.流行病学监测流行病学监测农场工人农场工人农场工人这种细菌是Mycobacterium bovis.动物性传染病动物性传染病

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