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Updated: May 25, 2025

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
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A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

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16p11.2删除载体中的差异链接显示了大规模网络之间的异常连接

Abid Y Qureshi1, Jared A Nielsen2, Jorge Sepulcre3,4

  • 1Department of Neurology, University of Kansas Medical Center, 2100 W 36th Ave, Suite 130J, Kansas City, KS 66103, United States.

Cerebral cortex (New York, N.Y. : 1991)
|February 26, 2025
PubMed
概括

16p11.2删除载体中独特的大脑连接模式,而不仅仅是改变了连接性,更好地解释了与自闭症相关的认知和行为变化. 特定的网络纠,特别是听觉和默认网络之间的纠,与社会障碍相关.

关键词:
自闭症谱系障碍 - 自闭症谱系障碍连接性的连接性.副本数量变化的变化功能性核磁共振成像 (MRI) 的功能性核磁共振成像大规模的大脑网络.

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