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三级淋巴体结构对未分化形肉瘤预后和瘤微环境的影响

Hiroki Sonoda^1,2, Takeshi Iwasaki¹, Shin Ishihara^1,2,3

¹Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

|February 26, 2025

概括

无差异性多形肉瘤 (UPS) 中的三级淋巴体结构 (TLS) 与更好的生存率有关,并可能预测对抗PD-1 免疫疗法的反应. 内TLS特别显示出作为免疫检查点抑制剂疗效的生物标志物的潜力.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

不分化的多形肉瘤 (UPS) 显示了对抗PD-1疗法的有希望的响应率.
三级淋巴体结构 (TLS) 被认为是免疫检查点抑制剂 (ICI) 的有利预后指标和生物标志物.
关于瘤微环境 (TME) 影响肉瘤ICI反应的数据有限.

研究的目的:

调查TLS在UPS的预后影响.
分析TLS与瘤微环境 (TME) 之间的关系.
评估TLS作为UPS中ICI响应的潜在生物标志物.

主要方法:

追溯分析52个UPS病例的广泛切除.
分类为内TLS,外TLS和没有TLS的组.
生存分析,免疫细胞和检查点分子的免疫组织化学,T细胞耗尽的多重免疫光学.

主要成果:

在65%的病例中检测到TLS (44%的内,21%的外).
与没有TLS的患者相比,TLS患者的整体存活时间明显更长 (p=0.020).
内TLS组显示免疫细胞增加,PD-L1和IDO-1表达,以及原始体耗尽的T细胞.

结论:

在UPS患者中,TLS是有利的预后因素.
内TLS可以作为对抗PD-1药物和其他UPS中的ICI反应的预测生物标志物.
研究结果有助于预测UPS的预后,并指导UPS的免疫治疗选择.

关键词:

T细胞耗尽的情况免疫检查点分子分子免疫检查点三级淋巴体结构的第三级淋巴体结构瘤微环境是一个微环境.没有区分的多形状肉瘤.

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