奇托桑鼻凝在治疗嗅觉功能障碍方面的治疗潜力:临床试验和机制研究
Majed A Algarni1, Mohamed H Abdelazim2, Fahad T Alsulami1
1Department of Clinical Pharmacy, College of Pharmacy, Taif University, Taif, Saudi Arabia.
American journal of rhinology & allergy
|February 26, 2025
概括
奇托桑鼻凝可以改善嗅觉功能,并降低持续嗅觉功能障碍患者的鼻水平. 需要进一步的研究来证实这些发现的嗅觉受体神经元再生.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经科学是一个神经科学.
- 生物材料科学 生物材料科学
背景情况:
- 嗅觉功能障碍显著影响生活质量,嗅觉受体神经元 (ORN) 对于嗅觉检测至关重要.
- 环境因素可能会损害ORN功能,鼻粘液水平升高与嗅觉功能障碍有关.
- 对于恢复嗅觉功能,ORN的再生至关重要.
研究的目的:
- 评估基托桑鼻凝在治疗持续性嗅觉功能障碍 (持续时间>6个月) 的有效性.
- 评估基托桑对嗅觉受体神经元再生和鼻水平的影响.
- 调查嗅觉功能领域的潜在改善.
主要方法:
- 一个随机的双盲试验,涉及215名持久性嗅觉功能障碍的参与者.
- 参与者接受了鼻腔奇托桑凝或化控制凝3个月.
- 用Sniffin' Sticks测试评估嗅觉功能,并在治疗前后测量鼻水平.
主要成果:
- 奇托桑鼻凝显著改善了嗅觉区分和识别得分,但不是值.
- 总体TDI得分提高了4.55分,低于5.5分的临床意义值.
- 与对照组相比,素治疗导致鼻分泌水平显著降低.
结论:
- 奇托桑鼻凝显示出改善嗅觉功能障碍的特定方面以及降低鼻水平的潜力.
- 该研究强调,需要进行更大规模,多样化的试验,随访时间更长,以验证这些初步结果.
- 目前的研究结果表明,素可能是治疗耐药性嗅觉功能障碍的一种有前途的治疗药物.
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