非侵袭性耳膜虚神经刺激降低了独立于热量负荷的心率变化
Kristin Kaduk1,2, Alessandro Petrella1, Sophie J Müller1
1Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health, University of Tübingen, Tübingen, Germany.
Psychophysiology
|February 26, 2025
概括
通过皮肤进行的耳膜迷走神经刺激 (taVNS) 并没有改变心率,但降低了心率变化率 (HRV),特别是RMSSD和HF-HRV. 这些效应在各种刺激方面都是一致的,并且独立于生理状态.
科学领域:
- 神经科学是一个神经科学.
- 心血管生理学心血管生理学
- 自主神经系统研究 自主神经系统研究
背景情况:
- 迷走神经在调节心血管功能方面发挥着关键作用.
- 通过皮肤进行耳道迷走神经刺激 (taVNS) 探索调节自主活动,但其对心率 (HR) 和心率变化 (HRV) 的影响是不一致的,对右侧刺激的数据有限.
- 现有研究经常假设taVNS增加心血管活动,反映在增加的HRV.
研究的目的:
- 调查taVNS对HR和HRV的影响.
- 为了比较左耳与右耳刺激对心血管指数的影响.
- 评估taVNS效应是否与生理状态相互作用,例如食后变化.
主要方法:
- 一项随机交叉研究,涉及36名健康参与者.
- 电心电图记录了每个参与者的四次会议,包括基线,taVNS (左耳或右耳) 或假刺激,以及消费后阶段.
- 使用SDRR,RMSSD,HF-HRV和LF/HF比率进行HRV分析.
主要成果:
- 适度的证据表明taVNS不会显著影响HR.
- taVNS显示整体HRV显著下降,有强有力的证据表明RMSSD和HF-HRV的减少,无论刺激方面或生理状态如何.
- 刺激效应在左和右的taVNS之间是可比的,并且比假刺激更强.
结论:
- 在不改变HR的情况下,taVNS降低了HRV (RMSSD,HF-HRV,SDRR),挑战了它固有地增加心血管度的概念.
- 这些发现表明,taVNS诱导的HRV变化可能反映了由阴道 afferent激活介导的兴奋,而不是直接的心血管增强.
- 双边taVNS在健康个体中对心血管系统进行调节是安全的,提供了潜在的治疗途径,而没有像白心脏这样的风险.
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