优化鼻内阿米苏尔普里德载荷纳米结构脂质载体:配方,开发和表征参数
Manar Adnan Tamer1, Hanan Jalal Kassab1
1Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Iraq.
Pharmaceutical nanotechnology
|February 26, 2025
概括
这项研究开发了阿米苏普里德的鼻内纳米结构脂质载体 (NLC),增强了其溶解和生物可用性. 优化的NLC配方表现出有利的特征和安全性,用于鼻分娩.
科学领域:
- 制药科学 制药科学
- 纳米技术纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 纳米结构脂质载体 (NLCs) 是基于脂质的先进纳米粒子.
- NLCs由由表面活性剂稳定的固体和液体脂质组成.
- 它们为改善药物输送系统提供了潜力.
研究的目的:
- 为了配制含有阿米苏普利的鼻内纳米结构脂质载体 (NLC).
- 通过鼻内输送增强阿米苏普利德的溶解和生物可用性.
- 通过改变脂质和表面活性剂成分来优化NLC配方.
主要方法:
- 使用超声波制备阿米苏尔普里德NLCs.
- 使用了各种固体脂质 (牛油酸,棕酸,糖单酸) 和液体脂质 (油酸,Imwitor 988,异氨基胺基酸).
- 评估了表面活性剂 (cremophor®EL,tween 80, span 20) 和辅助表面活性剂 (Transcutol HP,三氨酸,甘醇).
主要成果:
- 配方成分显著影响了NLC特征,如粒子大小,泽塔潜力和捕获效率.
- 最佳配方 (F19) 的粒子大小为68.309nm,泽塔电位为-20.64mV,捕获效率高 (95.75%).
- 观察到双相药物释放模式,并发现该配方在绵羊鼻膜上是安全的.
结论:
- 优化的鼻内NLC为阿米苏普利的输送提供了一个有前途的方法.
- 精心选择配方成分对于成功使用阿米硫载荷NLC至关重要.
- 这一策略增强了药物溶解和生物可用性,可用于鼻服.
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