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Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
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在精神分裂症谱系障碍中估计多模式结构性大脑变异性:全球ENIGMA研究

Wolfgang Omlor1, Finn Rabe1, Simon Fuchs1

  • 1Psychiatric Hospital, University of Zurich, Zurich (Omlor, Rabe, Fuchs, Surbeck, Cecere, Huang, S. Homan, Kallen, Georgiadis, Spiller, Seifritz, Kirschner, P. Homan); Neuroscience Center Zurich, University of Zurich and Swiss Federal Institute of Technology Zurich, Zurich (Huang, P. Homan); Department of Neuroscience and Physiology, Upstate Medical University, Syracuse, NY (T. Weickert, C. Weickert); Edith Collins Centre, Sydney Local Health District, Sydney (Bruggemann); Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior (Potkin, van Erp), and Center for the Neurobiology of Learning and Memory (van Erp), University of California Irvine, Irvine; Department of Pathology of Mental Diseases, National Center of Neurology and Psychiatry, National Institute of Mental Health, Tokyo (Hashimoto); Institute of Mental Health, Singapore (Sim); Psychology Department and Neuroscience Institute, Georgia State University, Atlanta (Rootes-Murdy); School of Psychology, University of New South Wales, Sydney (Quide); Hopitaux Universitaires Henri Mondor, Crétail, France (Houenou); Neuropsychiatry Laboratory, Department of Clinical Neuroscience and Neurorehabilitation, Santa Lucia Foundation IRCCS, Rome (Banaj, Vecchio, Fabrizio Piras, Federica Piras, Spalletta); FIDMAG Sisters Hospitallers Research Foundation, Barcelona, Spain (Salvador, Karuk, Pomarol-Clotet); Department of Psychiatry, Boston Children's Hospital, Harvard Medical School, Boston (Rodrigue, Glahn); Department of Psychiatry, Yale University, New Haven, CT, and Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, Hartford, CT (Pearlson); National Institute of Mental Health, Klecany, Czech Republic (Tomecek, Spaniel, Skoch); Division of Adult Psychiatry, Department of Psychiatry, Geneva University Hospitals, Geneva (Kirschner, Kaiser); Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore (Kochunov); Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing (Fan); NORMENT Center, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, and K.G. Jebsen Center for Neurodevelopment, University of Oslo, Oslo (Andreassen, Westlye, Berthet); Neuroscience Institute (Howells) and Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa (Howells, Uhlmann); Department of Child and Adolescent Psychiatry, Technische Universität Dresden, Dresden, Germany (Uhlmann); SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Neuroscience Institute, University of Cape Town, Cape Town, South Africa (Scheffler, Stein); Laboratory of Molecular and Translational Psychiatry and Unit of Treatment Resistant Psychosis, Section of Psychiatry, Reproductive and Odontostomatological Sciences, Department of Neuroscience, University of Naples Federico II, Naples (Iasevoli); Neuroscience Research Australia, Sydney (T. Weickert, C. Weickert, Bruggemann, Quide); School of Psychiatry, University of New South Wales, Sydney (T. Weickert, C. Weickert, Bruggemann); Specialty of Addiction Medicine, Central Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney (Bruggemann); Department of Psychiatry and Behavioral Health, Wexner Medical Center, Ohio State University, Columbus (Turner); Tri-Institutional Center for Translational Research in Neuroimaging and Data Science, Georgia State University, Georgia Institute of Technology, Emory University, Atlanta (Calhoun); School of Biomedical Sciences and Pharmacy (Cairns, Scott), Centre for Brain and Mental Health Research (Cairns, Loughland, Schall), School of Medicine and Public Health, College of Health, Medicine, and Wellbeing (Henskens, Rasser), Priority Research Centre for Health Behaviour (Henskens), and School of Psychological Sciences (Michie), University of Newcastle, Callaghan, Australia; Hunter Medical Research Institute, New Lambton Heights, Australia (Cairns, Loughland, Schall); School of Clinical Medicine, Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney (Carr, Green); Neuroscience Research Australia, Randwick (Carr, Green); Department of Psychiatry, Monash University, Clayton, Australia (Carr); School of Medicine, University of Queensland, Brisbane, Australia (Catts); Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, Australia (Di Biase, Klauser, Pantelis, Zalesky); Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston (Di Biase); University of Western Australia, Perth (Jablensky); Hunter Medical Research Institute, Newcastle, Australia (Henskens, Michie); Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences and Monash Biomedical Imaging, Monash University, Clayton, Australia (Klauser); Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (Klauser); Queensland Brain Institute and Queensland Centre for Mental Health Research, University of Queensland, Brisbane, Australia (Mowry); Florey Institute of Neuroscience and Mental Health, Parkville, Australia (Pantelis); Melbourne School of Engineering, University of Melbourne, Parkville, Australia (Zalesky); Section of Psychiatry, Department of Neuroscience (de Bartolomeis, Barone, Ciccarelli), Department of Advanced Biomedical Sciences (Brunetti, Cocozza, Pontillo, Tranfa), and Department of Electrical Engineering and Information Technology (Pontillo), University Federico II, Naples; ASST Papa Giovanni XXIII, Mental Health Department, Bergamo, Italy (Di Giorgio); Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles (Thomopoulos, Jahanshad, Thompson).

The American journal of psychiatry
|February 26, 2025
PubMed
概括

精神分裂症患者在前和皮下区域表现出更大的大脑结构变异性,与症状有关. 然而,特定大脑区域的折叠模式保持一致,表明有发育差异.

关键词:
神经成像是一种神经成像.神经科学是一个神经科学.精神分裂症谱系和其他精神病障碍

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科学领域:

  • 神经成像是一种神经成像.
  • 精神病学是一个精神病学.
  • 大脑结构 大脑结构

背景情况:

  • 精神分裂症呈现出各种不同的临床症状,反映出潜在的结构性大脑变异性.
  • 这种大脑异质性在灰质和白质特征中的分布尚未完全理解.
  • 研究多式结构指标对于了解精神分裂症的神经生物学基础至关重要.

研究的目的:

  • 研究精神分裂症中大脑异质性如何分布在多式结构指标上.
  • 检查皮质厚度,表面积,折叠指数,皮质下体积和分数异构的变化和平均值.
  • 在精神分裂症中将结构变异性与精神病理症状领域相关联.

主要方法:

  • 使用了ENIGMA数据集,包括来自22个国际站点的基于MRI的大脑测量.
  • 包括多达6037名精神分裂症患者和健康对照对特定的大脑测量.
  • 分析了皮层厚度,表面积,折叠指数,皮层下体积和分数异构的可变性和平均值.

主要成果:

  • 精神分裂症患者表现出皮质厚度,表面积,皮质下体积和前和皮质下网络中的微分异性变异性增加.
  • 这种增加的结构变异性主要与精神病理症状领域有关.
  • 意想不到的是,精神分裂症患者的折叠模式更为均,特别是在右尾前带区域,与对照组相比,平均折叠值没有显著差异.

结论:

  • 在右尾前带带区域的均折叠模式与精神分裂症中前和皮层网络的多式变异性形成对比.
  • 前和下皮层网络的变化与与疾病相关的多样性相关.
  • 均折叠可能表明在特定大脑区域的神经发育过程中,遗传和环境因素之间的相互作用不那么灵活.