硫化和对精子功能和氧化应激的影响在引起疹的老鼠中
Elham Ghajari1,2, Marziyeh Tavalaee3, Mohammad Hassan Meshkibaf1
1Department of Clinical Biochemistry, Faculty of Medicine, Fasa University of Medical Sciences, Fasa, Iran.
Cell journal
|February 26, 2025
概括
硫化 (NaHS) 补充剂改善了精子质量,并降低了患有静脉的老鼠的氧化应激. 治疗持续时间影响了对精子参数和抗氧化剂标记物的积极影响.
科学领域:
- 生殖生物学 生殖生物学
- 氧化压力研究研究 氧化压力研究
- 药理学 药理学是指药理学的学科.
背景情况:
- 男人不孕症的常见原因是静脉,与精子功能受损和氧化应激增加有关.
- 硫化 (H2S) 捐赠者,如硫化 (NaHS),正在研究其潜在的治疗作用.
研究的目的:
- 为了评估NaHS补充剂对精子参数和氧化应激标志物的影响,在实验诱导的小鼠模型中进行了测试.
主要方法:
- 威斯塔鼠被分为静脉,对照和假的群体.
- 静脉小组接受了不同时间的NaHS治疗 (手术后立即进行4个月或手术后2-4个月).
- 评估了精子参数,丸甲酸 (MDA) 和总抗氧化能力 (TAC).
主要成果:
- 静脉诱导对精子参数和功能产生了负面影响.
- NaHS治疗改善了精子度,运动性,染色质状态,并减少了细胞内活性氧物种 (ROS).
- NaHS降低了丸MDA水平和调节了TAC,效果因治疗时间而异.
结论:
- 补充NaHS在老鼠中显示出对 varicocele诱导的损伤的保护作用.
- 对精子参数和氧化应激的NaHS的治疗益处取决于治疗的持续时间.
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